Preparation and characterization of chitosan microparticles for oral sustained delivery of gliclazide: in vitro/in vivo evaluation

Barakat, Nahla S.; Almurshedi, Alanood S.

doi:10.1002/ddr.20389

Cited by 13 publications

(7 citation statements)

References 72 publications

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“…[ 36 ] . With the addition of Res, the viscosity of the droplet solution increased, which offset some portion of the shear force function and diminished droplet dispersion and subdivision during the emulsion procedure [ 37 ]. The microspheres were injected easily through needles of various sizes, including smaller 26-gauge, and showed no tendency of obstructing the needles ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

et al. 2021

Bioactive Materials

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The development of functional materials for osteoporosis is ultimately required for bone remodeling. However, grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone formation. In this work, nano-hydroxyapatite (n-HA)/resveratrol (Res)/chitosan (CS) composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of Res. Study of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res release. Notably, microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α, IL-1β and iNOS in RAW264.7 cells in a dose dependent manner. Further, enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell growth. The ability to enhance osteo-differentiation was supported by up-regulation of Runx2, ALP, Col-1 and OCN, and substantial mineralization in osteogenic medium. When implanted into bone defects in the osteoporotic rat femoral condyles, enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture healing. The results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

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Section: Resultsmentioning

confidence: 99%

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

et al. 2021

Bioactive Materials

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“…They can be obtained either by association with small anionic molecules, by hydrogen bonding, by hydrophobic associations, or by polyanions [ 22 ]. Among them, ionotropic gelation of chitosan by polyanions, particularly by tripolyphosphate (TPP), a non-toxic polyanion that can interact with chitosan via electrostatic forces to form ionic crosslinked networks, has been widely used [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Ionically crosslinked chitosan hydrogels can be used as drug delivery systems for controlled release not only in acidic but also in basic media, for rapid release by dissolution and as thermogelling systems.…”

Section: Introductionmentioning

confidence: 99%

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

et al. 2018

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The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

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“…Tripolyphosphate (TPP) is by far the most employed cross-linker to ionically reticulate chitosan due to its high net negative charges (ranging from one to five depending on pH) per monomeric unit and nontoxicity [116,141,142]. TPP has been widely exploited in pharmaceutical field to obtain chitosan microparticles [143][144][145], nanoparticles [143,146] and nano/micro-gels [147,148] intended for controlled drug delivery [149].…”

Section: Chitosan Ionic Cross-linkingmentioning

confidence: 99%

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

et al. 2020

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Polysaccharide-based hydrogel particles (PbHPs) are very promising carriers aiming to control and target the release of drugs with different physico-chemical properties. Such delivery systems can offer benefits through the proper encapsulation of many drugs (non-steroidal and steroidal anti-inflammatory drugs, antibiotics, etc) ensuring their proper release and targeting. This review discusses the different phases involved in the production of PbHPs in pharmaceutical technology, such as droplet formation (SOL phase), sol-gel transition of the droplets (GEL phase) and drying, as well as the different methods available for droplet production with a special focus on prilling technique. In addition, an overview of the various droplet gelation methods with particular emphasis on ionic cross-linking of several polysaccharides enabling the formation of particles with inner highly porous network or nanofibrillar structure is given. Moreover, a detailed survey of the different inner texture, in xerogels, cryogels or aerogels, each with specific arrangement and properties, which can be obtained with different drying methods, is presented. Various case studies are reported to highlight the most appropriate application of such systems in pharmaceutical field. We also describe the challenges to be faced for the breakthrough towards clinic studies and, finally, the market, focusing on the useful approach of safety-by-design (SbD).

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Preparation and characterization of chitosan microparticles for oral sustained delivery of gliclazide: in vitro/in vivo evaluation

Cited by 13 publications

References 72 publications

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

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