Preparation and characterization of chitosan—Polyethylene glycol‐polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study

Abstract

In the present research work, the anticancer drug "curcumin" is loaded with Chitosan (CS)-polyethylene glycol (PEG)-polyvinylpyrrolidone (PVP) (CS-PEG-PVP) polymer nanocomposites coated with superparamagnetic iron oxide (Fe3 O4 ) nanoparticles. The system can be used for targeted and controlled drug delivery of anticancer drugs with reduced side effects and greater efficiency. The prepared nanoparticles were characterized by Fourier transmission infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Curcumin drug-loaded Fe3 O4 -CS, Fe3 O4 -CS- PEG and Fe3 O4 -CS-PEG-PVP nanoparticles exhibited the mean particle size in the range of 183 - 390 nm with a zeta potential value of 26 mV-41 mV as measured using Malvern Zetasizer. The encapsulation efficiency, loading capacity and in-vitro drug release behaviour of curcumin drug-loaded Fe3 O4 -CS, Fe3 O4 -CS-PEG, and Fe3 O4 -CS-PEG-PVP nanoparticles were studied using UV spectrophotometer. Besides, the cytotoxicity of the prepared nanoparticles using MTT assay was also studied. The curcumin drug release was examined at different pH medium (4.5 and 7.4) and temperature (37°C and 45°C), and it was proved that the drug release depends upon the pH medium and temperature in addition to the nature of matrix.

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

“…Alternative drugs may also be linked to nanosystems. Curcumin, a natural polyphenolic hydrophobic compound from Curcuma longa rhizomes, has been incorporated into IONPs for preventing and fighting cancer [ 10 , 106 , 133 , 173 , 174 , 175 ]. It is believed that this herbal product remains captured at the hydrophobic interface between components of surfactant-stabilized nanocarriers [ 133 ].…”

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

“…The reduction of saturation magnetization of MNPs after polymeric encapsulation has already been reported in the literature. Santos et al (2018), [8] Prabha and Raj (2016), [45] and Batch et al (2012) [46] observed a reduction of 50%, 41%, and 49% in the saturation magnetization of MNPs after encapsulation in poly(thioether-ester), chitosan and, PMMA NPs, respectively. The superparamagnetic profile is es- sential for MNPs to exert hyperthermic effects and to be directed to specific targets.…”

Design of Sustained Action Dosage Forms; Mini-Review

“…The results showed that the release rate was controlled mostly by drug diffusion rather than polymeric dissolution. Thus, even when drugs are incorporated in a water-soluble matrix which will be subjected to erosion, the rate-limiting step is diffusion of the drug out of the matrix [9,[35][36][37].…”