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The aim of the present study is to examine the feasibility of Cassava starch acetate (CSA)-polyethylene glycol (PEG)-gelatin (G) nanocomposites as controlled drug delivery systems. It is one of the novel drug vehicles which can be used for the controlled release of an anticancer drug. Simple nano precipitation method was used to prepare the carriers CSA-PEG-G nanocomposites and they were used for entrapping cisplatin (CDDP). Through FT-IR spectroscopy, the linking among various components of the system was proved and with the help of scanning electron microscope and transmission electron microscopy (TEM), the surface morphology was investigated. The particle sizes of the CSA-CDDP, CSA-CDDP-PEG and CSA-CDDP-PEG-G polymer composites were between 140 and 350 nm, as determined by a Zetasizer. Drug encapsulation efficiency, drug loading capacity and in vitro release of CDDP were evaluated respectively. The findings revealed that the cross linked CSA-PEG-G nanocomposites can be a potential polymeric carrier for controlled delivery of CDDP.

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In the present research work, the anticancer drug "curcumin" is loaded with Chitosan (CS)-polyethylene glycol (PEG)-polyvinylpyrrolidone (PVP) (CS-PEG-PVP) polymer nanocomposites coated with superparamagnetic iron oxide (Fe3 O4 ) nanoparticles. The system can be used for targeted and controlled drug delivery of anticancer drugs with reduced side effects and greater efficiency. The prepared nanoparticles were characterized by Fourier transmission infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Curcumin drug-loaded Fe3 O4 -CS, Fe3 O4 -CS- PEG and Fe3 O4 -CS-PEG-PVP nanoparticles exhibited the mean particle size in the range of 183 - 390 nm with a zeta potential value of 26 mV-41 mV as measured using Malvern Zetasizer. The encapsulation efficiency, loading capacity and in-vitro drug release behaviour of curcumin drug-loaded Fe3 O4 -CS, Fe3 O4 -CS-PEG, and Fe3 O4 -CS-PEG-PVP nanoparticles were studied using UV spectrophotometer. Besides, the cytotoxicity of the prepared nanoparticles using MTT assay was also studied. The curcumin drug release was examined at different pH medium (4.5 and 7.4) and temperature (37°C and 45°C), and it was proved that the drug release depends upon the pH medium and temperature in addition to the nature of matrix.

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