Preparation and characterization of crosslinked poly(methylmethacrylate‐acrylic acid sodium salt)‐modified bone cement

Abstract

Bone cement is used as load‐distributing filler between the prosthesis and the bone as well as a method to anchor prosthesis in orthopedic implants. In this study, crosslinked poly(methylmethacrylate‐acrylic acid sodium salt), denoted as poly(MMA‐AAS‐AMA), was applied to bone cement. Allylmethacrylate (AMA) was used as a crosslinking agent. It was demonstrated by FTIR that the wavenumbers of the asymmetrical and symmetrical stretching vibrations for carboxylate anion of poly(MMA‐AAS‐AMA) were 1586 and 1407 cm−1, respectively. The poly(MMA‐AAS‐AMA)‐modified bone cement was prepared and characterized using tensile and compressive test. An excess of poly(MMA‐AAS‐AMA) in bone cement caused poor mechanical properties of the modified bone cement, because poly(MMA‐AAS‐AMA) absorbed water. In dynamic mechanical analysis, the excessive content of poly(MMA‐AAS‐AMA) lowered the stiffness of the modified bone cement, because of water existed in poly(MMA‐AAS‐AMA). The glass transition temperature of the bone cement shifted to higher temperature at higher frequency because of viscoelasticity. Based on swelling measurement, the modified bone cement was able to swell in controlled manner, and the swelling rate of the modified bone cement was improved. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

Preparation and characterization of acrylic bone cement with high drug release

“…The compressive strength of bone cement usually varies from 44 to 103 MPa [18]. The compressive strength of the Osteobond bone cement (105.3±21.9 MPa, tested after immersion in saline solution at 37°C for 50 days) [27] is higher than that of the conventional bone cement loaded with ketoprofen (75.8± 9.2 MPa, tested after immersion in PBS at 37°C for 107 days), because drug-loaded cement is mechanically Table 2 The initial ketoprofen release rate as calculated over the first 6 h of release and total ketoprofen release after 1 week as a percentage of the total amount.…”

A Phase Diagram of the P3HT:PCBM Organic Photovoltaic System: Implications for Device Processing and Performance

“…In the absence of second-order transitions at lower temperatures, and as this transition is likely to be the limiting factor in the processing of devices, we will label this transition T g . While we have used a number of frequencies during temperature scans to aid in transition identification, we will use 1 Hz data for measurement of the glass transition temperature and the peak of tan δ as the T g (in common with other DMTA reports ,,, ).…”