Preparation and Characterization of Dexamethasone Microemulsion Based on Pseudoternary Phase Diagram

Moghimipour, Eskandar; Salimi, Anayatollah; Karami, Masoud Ali; Isazadeh, Sara

doi:10.17795/jjnpp-9373

Cited by 52 publications

(52 citation statements)

References 17 publications

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“…Pseudo ternary phase diagram is plotted by using Chemix software. 8,9 After 24 h, when mixture formed equilibrium at room temperature then evaluated for appearance, clarity, viscosity. Stable micro emulsion further also observed under polarizing light to confirm their isotropic nature.…”

Section: Surfactant and Co-surfactant Screeningmentioning

confidence: 99%

Solubility Enhancement of Nebivolol by Micro Emulsion Technique

Nemichand¹,

Laxman²

2016

JYP

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Nebivolol is a third-generation beta-a drenoceptor antagonist. It differs from other beta-a drenoceptor an tagonists as it combines highly selective beta (1)-adrenoceptor antagonist properties with nitric oxide-mediated vasodilator actions and beneficial effects on endothelial function. But this very useful drug use is limited due to challenge of poor water solubility (0.0403 mg/ml). Present study deals with enhancement of solubility of Nebivolol by micro emulsion technique. Various oils, surfactants, and co-surfactants were used to check solubility of Nebivolol. Pseudoternary phase diagrams were constructed using various combinations of ingredients i.e. oil: surfactant: co-surfactant. Micro emulsion batches were prepared by phase titration method. Developed micro emulsion was evaluated for various physicochemical, stability parameters, in-vitro and ex-vivo parameters. Results showed stable micro emulsion form of Nebivolol improved solubility.

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Section: Surfactant and Co-surfactant Screeningmentioning

confidence: 99%

Solubility Enhancement of Nebivolol by Micro Emulsion Technique

Nemichand¹,

Laxman²

2016

JYP

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“…The formulations were diluted in distilled water (1:15), homogenized until completely dispersed and then subjected to analysis, which was performed in triplicate (Silveira, 2009;Moghimipour, Salimi, Leis, 2012).…”

Section: Zeta Potentialmentioning

confidence: 99%

“…The sample was diluted with distilled water (1:10) and placed in cuvettes of 1 cm³ volume at a temperature of 25 °C. The measurements were performed in triplicate (Kale, Allen Jr, 1989;Silveira, 2009;Moghimipour, Salimi, Leis, 2012).…”

Section: Dynamic Light Scattering (Dls)mentioning

confidence: 99%

“…Pereira (2008) used the same parameters but for olive oil, grape seed oil and a mixture of both and found that the systems showed optimal stability when using a pair of surfactants (Ultroil R300 ® and Span ® 80) whose HLB was equal to 8. Kale, Allen Jr (1989), Yaghmur et al (2002), Yotsawimonwat et al (2006) and Moghimipour, Salimi, Leis (2012) used propylene glycol as co-surfactant in different formulations of microemulsions.…”

Section: Surfactant and Cosurfactant Systemmentioning

confidence: 99%

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Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Pascoa

Diniz

Florentino

et al. 2015

Braz. J. Pharm. Sci.

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This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone ® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1 st , 7 th , 15 th , and 30 th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p < 0.05) than the oil when applied directly to the ear. Descrevemos o desenvolvimento de um produto farmacêutico contendo ativo vegetal baseado em uma planta medicinal brasileira. Foi avaliada a habilidade de formação de uma microemulsão à base do óleo de Pterodon emarginatus (sucupira) e seu potential anti-inflamatório. Uma formulação foi desenvolvida utilizando o óleo de P. emarginatus, mistura de óleo de mamona etoxilado (Ultramona ® R-540)/propilenoglicol (2:1) (tensoativo/cotensoativo) e água destilada, na proporção de 10:15:75, respectivamente. A microemulsão selecionada foi submetida ao teste preliminar de estabilidade e foi analisada quanto ao diâmetro médio das gotículas, pH, potential zeta e índice de polidispersão, no 1º, 7º, 15º e 30º dias após o preparo e foram estocadas em diferentes temperaturas (5±2 °C, 25±2 °C e 40±2 °C). Avaliaram-se a atividade anti-inflamatória in vivo do óleo de sucupira e da formulação, usando o modelo experimental do edema de orelha induzido pelo óleo de cróton. No teste preliminar de estabilidade observou-se que a formulação estocada a 5 °C e a 25 °C mantiveram suas características originais durante 30 dias. O potencial anti-inflamatório de ambos, óleo de sucupira e formulação foi estatisticamente significativo (p <0.001), quando comparado ao controle, porém a microemulsão foi mais eficiente (p <0.05) que o óleo aplicado diretamente nas orelhas dos animais. Unitermos:Pterodon emarginatus/pharmacognosy. Pterodon emarginatus/óleo/atividade antiinflamatória. Plantas medicinais. Microemulsão. Fitoterápico. Tecnologia farmacêutica.

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“…The mixture of oil and at different ratio of Smix (1:0.5, 1:1, 1.5:1, 2:1, 2.5:1 and 3:1) at certain volume ratio were titrated with distilled water in drop wise manner. Using Chemix software, microemulsion regions were determined and Smix showing maximum microemulsion region was used for the development of microemulsion (Moghimipour, Anayatollah, Fatemeh, 2012;Subudhi, Mandal, 2013).…”

Section: Pseudoternary Phase Diagram Studymentioning

confidence: 99%

Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route

Mandal

Chuttani

et al. 2015

Braz. J. Pharm. Sci.

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This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of ibuprofen via nasal route was studied by performing biodistribution study in Swiss albino rats. MEI was found to be transparent, stable and non ciliotoxic with 66.29 ± 4.15 nm, -20.9 ± 3.98 mV and 98.66 ± 1.01% as average globule size, zeta potential and drug content respectively. Transmission Electron Microscopy (TEM) study revealed the narrow globule size distribution of MEI. Following single intranasal administration of MMEI and MEI at a dose of 2.86 mg/kg, uptake of ibuprofen in the olfactory bulb was around 3.0 and 1.7 folds compared with intravenous injection of ibuprofen solution (IDS). The ratios of AUC in brain tissues to that in plasma obtained after nasal administration of MMEI were significantly higher than those after intravenous administration of IDS. Findings of the present investigation revealed that the developed mucoadhesive microemulsion gel could be a promising approach for brain targeting of ibuprofen through intranasal route.Uniterms: Ibuprofen/brain-targeting. Ibuprofen/intranasal administration. Ibuprofen/mucoadhesion. Mucoadhesive microemulsion gel. Drugs/design. Transmission electron microscopy.O objetivo deste trabalho foi planejar microemulsão/mucoaesiva em gel a fim de melhorar a captação cerebral de ibuprofeno por via intranasal. A microemulsão para mucoadesão com ibuprofeno (MMEI) foi desenvolvida pela incorporação de policarbofil como polímero mucoadesivo em microemulsão otimizada (MEI) com base em Capmul (MCM) e foi submetida à caracterização, estabilidade, mucoadesão e naso-ciliotoxicidade. A captação cerebral de ibuprofeno pela via nasal foi estudada por meio de estudo de biodistribuição em ratos albinos suíços. MEI se mostrou transparente, estável e não ciliotóxica, com 66,29 ± 4,15 nm, -20,9 ± 3,98 mV e 98,66 ± 1,01%, respectivamente, de tamanho médio dos glóbulos, potencial zeta e conteúdo do fármaco. O estudo revelou o estreita distribuição do tamanho dos glóbulos de MEI. Após administração intranasal única de MMEI e MEI, em dose de 2,86 mg/kg, a captação de ibuprofeno no bulbo olfativo foi em torno de 3,0 e 1,7 vezes maior, comparativamente, à injeção endovenosa de ibuprofeno (IDS). As taxas de ASC em tecido cerebral em relação ao plasma, obtidas após administração da MMEI nasal, foram, significativamente, mais elevadas do que aquelas observadas após a administração intravenosa de IDS. Os resultados do presente estudo mostraram que a microemulsão/mucoadesiva em gel poderia ser uma abordagem promissora para o direcionamento cerebral de ibuprofeno por via intranasal.Unitermos: Ibuprofeno/captação cerebral. Ibuprofeno/administração intranasal. Ibuprofeno/mucoadesão. Microemuls...

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Preparation and Characterization of Dexamethasone Microemulsion Based on Pseudoternary Phase Diagram

Cited by 52 publications

References 17 publications

Solubility Enhancement of Nebivolol by Micro Emulsion Technique

Solubility Enhancement of Nebivolol by Micro Emulsion Technique

Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route

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