Preparation and characterization of epigallocatechin gallate, ascorbic acid, gelatin, chitosan nanoparticles and their beneficial effect on wound healing of diabetic mice

Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals’ tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle’s promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant’s medical capabilities.

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“…Diabetic foot is one of the serious chronic complications of diabetes. Diabetic foot wounds are difficult to heal [10].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

2021

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“…An EGCG/PLGA membrane treatment greatly improved the infiltration of surrounding cells and increased the immunoreactivity of Ki-67 (re-epithelialization marker) and CD 31 (blood vessel formation marker) at the wound site of nude mice, implying that EGCG/PLGA membrane treatment is beneficial to wound healing by promoting cell infiltration, re-epithelialization and angiogenesis [ 23 ]. The gelatin and chitosan nanoparticles of EGCG and ascorbic acid have promoting effects on collagen accumulation and angiogenesis but an inhibitory effect on the infiltration of inflammatory cells at the wound area of diabetic mice [ 72 ]. The in vivo study showed an EGCG-containing sandwiched dressing facilitated wound tissue regeneration and accelerated the healing process [ 36 ].…”

Section: Beneficial Effects Of Egcg At Different Healing Stagesmentioning

confidence: 99%

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Zhong

et al. 2021

Molecules

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Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

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“…Sun and his team [72] created a novel nanoparticle in the hopes of aiding in the acceleration of chronic wound healing by incorporating various bioinert materials such as EGCG, ascorbic acid, gelatine, and chitosan to ensure cell biocompatibility. These nanoparticles are named EV NPS and this novel material has successfully shown better performance in vivo by completely healing a full-thickness skin wound within 10 days with thicker epithelium, abundant neovascular vessels, hair follicles, and other skin attachments compared to the control.…”

Section: Epigallocatechin Gallate (Egcg) Treatments For Wound Healingmentioning

confidence: 99%

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

Mazlan

2021

Polymers

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Immediate treatment for cutaneous injuries is a realistic approach to improve the healing rate and minimise the risk of complications. Multifunctional biomaterials have been proven to be a potential strategy for chronic skin wound management, especially for future advancements in precision medicine. Hence, antioxidant incorporated biomaterials play a vital role in the new era of tissue engineering. A bibliographic investigation was conducted on articles focusing on in vitro, in vivo, and clinical studies that evaluate the effect and the antioxidants mechanism exerted by epigallocatechin gallate (EGCG) in wound healing and its ability to act as reactive oxygen species (ROS) scavengers. Over the years, EGCG has been proven to be a potent antioxidant efficient for wound healing purposes. Therefore, several novel studies were included in this article to shed light on EGCG incorporated biomaterials over five years of research. However, the related papers under this review’s scope are limited in number. All the studies showed that biomaterials with scavenging ability have a great potential to combat chronic wounds and assist the wound healing process against oxidative damage. However, the promising concept has faced challenges extending beyond the trial phase, whereby the implementation of these biomaterials, when exposed to an oxidative stress environment, may disrupt cell proliferation and tissue regeneration after transplantation. Therefore, thorough research should be executed to ensure a successful therapy.

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Preparation and characterization of epigallocatechin gallate, ascorbic acid, gelatin, chitosan nanoparticles and their beneficial effect on wound healing of diabetic mice

Cited by 48 publications

References 24 publications

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

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