Preparation and Characterization of Genipin-Crosslinked Chitosan Microspheres for the Sustained Release of Salidroside

Abstract

Chitosan microspheres (CsMs) that encapsulate salidroside (Sal) were prepared by the emulsion crosslinking method with naturally occurring genipin (Gp) and then examined for their in vitro release. Sal-loaded CsMs (Sal-CsMs) showed nearly spherical and smooth surfaces with internal voids. The particle size of Sal-CsMs ranged within 0.56-5.01 μm, and their encapsulation efficiency and loading capacity were beyond 77.58% and 23.29%, respectively. The stability of Sal improved after entrapment into the CsMs. The release rate of Sal from CsMs was initially rapid, followed by sustained release. The release behavior depended on the pH of the release medium. The main release mechanisms underlying the release procedure were anomalous behavior and Fickian diffusion. These results indicated that CsMs with a novel crosslinker of Gp was a potential carrier system for producing functional foods containing Sal.

Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses

“…The studies by Luo et al (2015), showed when preparing chitosan microspheres by the emulsion crosslinking method using genipin (Gp) for in vitro studies of controlled release of salidroside and Zhang et al (2011), when carrying out a comparative investigation regarding the intestinal absorption of the inclusion complex genipin/hydroxypropyl-β-cyclodextrin (HP-β-CD) with that of genipin, they also observed the same characteristic peaks in the X-ray diffraction of genipin.…”

Therapeutic potential of phenylethanoid glycosides: A systematic review

“…The salidroside stability was improved after being entrapped into chitosan microspheres. The release rate of salidroside from chitosan microspheres was rapid initially, followed by controlled release 276 . Improved stability and controlled release of salidroside were also achieved through incorporation of salidroside into polymer network microspheres prepared by chitosanand methylcellulose 277 …”

“…The release rate of salidroside from chitosan microspheres was rapid initially, followed by controlled release. 276 Improved stability and controlled release of salidroside were also achieved through incorporation of salidroside into polymer network microspheres prepared by chitosanand methylcellulose. 277 To enhance the intestinal absorption and oral bioavailability, echinacoside-phospholipid complex was prepared.…”

Characterization of sustained-release chitosan film loaded with rutin-β-cyclodextrin complex and glucoamylase

“…Chitosan possesses excellent film-forming ability and is suitable for the formulation of edible films. Chitosan film is a convenient packaging material, and its different forms, such as composite, modified and sustainedrelease chitosan films have been extensively investigated (Luo et al 2015;Pranoto et al 2005). Chitosan films are used to reduce water vapour, oxygen, lipid and flavour migration between components of multi-component food products, and compositing is one of the useful methods to append functional properties to chitosan films (Rao et al 2010).…”