Preparation and characterization of highly pH-sensitive biodegradable poly(ether-ester-urethane) and its potential application for drug delivery

Hou, Zhaosheng; Teng, Jinwei; Wei, Jinjian; Tang, Hao; Liu, Zhengqi

doi:10.1016/j.mtcomm.2021.102527

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Hou et al reported on pH responsive PU loaded with cefazedone. 19 The PU was produced by reacting PEG, p-dioxanone with diphenylmethane diisocyanate (MDI) and conjugated with pyridine derivative content. Shoaib et al reported on the synthesis of pH responsive PU loaded with an anticancer drug, imatinib, in which the pH responsive PU was produced by reacting PEG with HDI and conjugated with several amino acid extenders including lysine, arginine and glutamine.…”

Section: Introductionmentioning

confidence: 99%

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pH‐responsive polyurethane‐acrylate from palm olein and sunflower oil: Sustainable synthesis, enhanced lovastatin solubility, and potential drug carrier for targeted delivery

Tan,

Lee,

Pichika

et al. 2024

J of Applied Polymer Sci

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A pH responsive non‐isocyanate polyurethane‐acrylate (NIPUA) is synthesized through utilizing palm olein and sunflower oil as feedstock. The unsaturated acyl chains of both vegetable oils are converted into epoxy rings through epoxidation and subjected to carbonation with binary catalytic system under a solventless and mild condition to produce the cyclic carbonates. The cyclic carbonates were reacted with 1,4‐butanediamine and itaconic acid to produce the NIPUA. The intermediates and product were characterized by FTIR spectroscopy, NMR spectroscopy and gel permeation chromatography. The NIPUA was incorporated with poly(vinyl pyrrolidone) (PVP) to form a polymer carrier system loaded with a hydrophobic model drug, lovastatin (LOV). All NIPUA/PVP preformulations demonstrated pH responsiveness, with 1 to 2‐folds enhanced solubility at pH 7.4 compared to pH 2.0. NIPUA/PVP exhibited solubility enhancer effect by significantly enhanced solubility (2–4 times) compared to pure LOV, LOV‐loaded PVP, and Medostatin tablets at both pH levels. LOV‐loaded NIPUA/PVP exhibited lower enthalpy energy in DSC thermogram than LOV‐loaded PVP, indicating disruption of LOV's crystalline structure. In MTT assay, IC50 values were 30.76 μg mL−1 for pure LOV and 273.53 μg mL−1 for NIPUA/PVP, demonstrating the potential of NIPUA as an environmentally friendly, pH responsive drug carrier for controlled release of poorly water‐soluble drugs.

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Section: Introductionmentioning

confidence: 99%

“…On the other hand, pH responsive polymers containing polycations were reported for their pH responsiveness at acidic pH condition. Hou et al reported on pH responsive PU loaded with cefazedone 19 . The PU was produced by reacting PEG, p ‐dioxanone with diphenylmethane diisocyanate (MDI) and conjugated with pyridine derivative content.…”

Section: Introductionmentioning

confidence: 99%

pH‐responsive polyurethane‐acrylate from palm olein and sunflower oil: Sustainable synthesis, enhanced lovastatin solubility, and potential drug carrier for targeted delivery

Tan,

Lee,

Pichika

et al. 2024

J of Applied Polymer Sci

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show abstract

“…[1][2][3]. Их широкая применимость связана не только с высоким терапевтическим действием, но и с такими свойствами, как биосовместимость, способность к преодолению биологических барьеров, биоразлагаемость [4][5][6]. Этими свойствами можно управлять, изменяя структуру молекул, содержащих карбаматный фрагмент, в частности, придавая им амфифильный характер путем введения гидрофобных заместителей.…”

Section: Introductionunclassified

Dicarbamate Surfactant – Tween 80 Binary Systems: Aggregation, Antimicrobial Activity and Membranotropic Properties

Kushnazarova¹,

Mirgorodskaya²,

Voloshina³

et al. 2022

Liq. Cryst. and their Appl.

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Preparation and properties of monomethoxyl polyethylene glycol grafted O-carboxymethyl chitosan for edible, fresh-keeping packaging materials

Yang

Yin

Bian

et al. 2022

Food Packaging and Shelf Life

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Preparation and characterization of highly pH-sensitive biodegradable poly(ether-ester-urethane) and its potential application for drug delivery

Cited by 4 publications

References 48 publications

pH‐responsive polyurethane‐acrylate from palm olein and sunflower oil: Sustainable synthesis, enhanced lovastatin solubility, and potential drug carrier for targeted delivery

pH‐responsive polyurethane‐acrylate from palm olein and sunflower oil: Sustainable synthesis, enhanced lovastatin solubility, and potential drug carrier for targeted delivery

Dicarbamate Surfactant – Tween 80 Binary Systems: Aggregation, Antimicrobial Activity and Membranotropic Properties

Preparation and properties of monomethoxyl polyethylene glycol grafted O-carboxymethyl chitosan for edible, fresh-keeping packaging materials

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