Preparation and characterization of injectable calcium phosphate cement paste modified by polyethylene glycol-6000

Chen, Fangping; Liu, Changsheng; Wei, Jie; Chen, Xiao; Zhao, Zhenyun; Gao, Yanli

doi:10.1016/j.matchemphys.2010.09.050

Cited by 21 publications

(13 citation statements)

References 14 publications

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“…Figure 6 shows the incorporation of PEG into CPC has improved setting time of CPC by shortening the hardening time of CPC. The dissolution of PEG in water formed a network structure leading to the entanglement with three dimensional apatite structures during the hydration process, and finally resulted in the acceleration of setting time [13,19]. This is true only for the addition of PEG content below 5%.…”

Section: Setting Timementioning

confidence: 99%

“…This result is in agreement with the study by Hesaraki et al [20] that revealed significant improvement of cement paste after PEG addition as compared with paste using water only because PEG lowered the friction between CPC particles. On the other hand, Chen et al [13] reported that injectability decreased when PEG concentration increased due to the increase in viscosity of cement paste. Hydration reaction between the PEG solution and CPC powder formed a spatial net structure via the formation of colloidal particles that join together through Van der Waals force, and hence strengthen the network of cement paste [13].…”

Section: Injectabilitymentioning

confidence: 99%

“…PEG is a polyether composed of glycerol monomers. It has been used in biomedical fields because of its non-toxicity, good water solubility, flexibility, and anti-coagulant activity [13]. PEG acts as a thickening agent and keeps the cement paste stable, which has been applied to prepared premixed CPCs [11,13].…”

Section: Introductionmentioning

confidence: 99%

“…It has been used in biomedical fields because of its non-toxicity, good water solubility, flexibility, and anti-coagulant activity [13]. PEG acts as a thickening agent and keeps the cement paste stable, which has been applied to prepared premixed CPCs [11,13]. With the addition of PEG, CPC is expected to have shorter setting time, better anti-washout performance, but lower injectability [11].…”

Section: Introductionmentioning

confidence: 99%

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Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

Hablee

Sopyan

Mel

et al. 2018

IIUMEJ

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The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa.. ABSTRAK: Penyelidikan ini melaporkan tentang kesan menambah polietilina glikol (PEG) terhadap sifat-sifat simen kalsium fosfat seperti keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Kalsium hidroksida dan diammonium hidrogen fosfat digunakan sebagai reagen dalam kaedah pemendakan kimia basah bagi menghasilkan serbuk hidroksiapatit. Pes simen disediakan dengan nisbah serbuk kepada cecair yang berbeza, dengan nisbah 1.0, 1.3, 1.5 dan 2.0. Kemudian, PEG ditambah ke dalam simen kalsium fosfat dengan kepekatan yang berbeza, bernilai 1, 2, 3, 4 dan 5 wt% bagi 1.3 nisbah serbuk kepada cecair. Simen yang terhasil diuji bagi menilai keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Keputusan ujian-ujian tersebut menunjukkan bahawa penambahan PEG ke dalam simen telah meningkatkan kebolehan simen untuk disuntik, mengurangkan masa pengerasan simen dan meningkatkan kekuatan mekanikal simen. Simen tanpa PEG mempunyai masa pengerasan awal daripada 3 min kepada 122 min dan masa pengerasan akhir daripada 5 min kepada 277 min. Apabila PEG ditambah, masa pengerasan simen menjadi lebih baik dengan masa pengerasan awal daripada 47 min kepada 88 min dan masa pengerasan akhir daripada 182 min kepada 228 min. Peningkatan dalam keupayaan simen untuk disuntik telah dibuktikan dengan pengurangan beban penyempitan apabila PEG ditambah ke dalam simen. Simen tanpa PEG mempunyai 82.5% keupayaan suntikan dan meningkat kepada 95.5% apabila 5% PEG ditambah. Kekuatan mampatan simen bernilai antara 0.59 dan 1.334 MPa dan keliangan simen bernilai antara 39.2% dan 47.1%. Kekuatan mampatan simen meningkat dengan ketara apabila PEG ditambah, bernilai antara 1.167 dan 1.786 Mpa.

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Section: Setting Timementioning

confidence: 99%

Section: Injectabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

Hablee

Sopyan

Mel

et al. 2018

IIUMEJ

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“…From these basic systems, secondary self-setting formulations could be derived containing additional or even non-reactive compounds [17,46,74,123,[126][127][128][129][130][131][132][133][134][135][136][137][138][139]. Concerning their viscosity, both pasties [140][141][142][143][144][145] and putties [146] of a very high viscosity [146][147][148][149] are known. …”

Section: General Information and Knowledgementioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Self-Setting Calcium Orthophosphate (CaPO4) Formulations

Dorozhkin¹

2017

Springer Series in Biomaterials Science and Engineering

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Preparation and characterization of injectable calcium phosphate cement paste modified by polyethylene glycol-6000

Cited by 21 publications

References 14 publications

Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate (CaPO4) Formulations

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