Preparation and characterization of intelligent core-shell nanoparticles based on poly(d,l-lactide)-g-poly(N-isopropyl acrylamide-co-methacrylic acid)

Lo, Chun Liang; Lin, Ko Min; Hsiue, Ging Ho

doi:10.1016/j.jconrel.2005.03.004

Cited by 155 publications

(100 citation statements)

References 29 publications

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“…For example, a liposome-based dual-targeted drug delivery system with two probes of FA and the antibody of epidermal growth factor receptor (EGFR) has been prepared to improve the selectivity of targeting human KB cells, which over-expresses both FA and EGFR receptors [28]. Also, upon the changes of local temperature and pH value around certain pathological microenvironments of tumors, the thermo and pH dual-responsive NPs, consisting of the temperatureresponsive polymer of poly(N-isopropylacrylamide) and the pH-responsive polymer of poly(N,N-dimethylarylamide) [29], poly(methacrylic acid) [30] or (acrylic acid) [31], have been developed as anticancer drug carriers. Additionally, in order to better recognize cancer receptors, the FA receptor targeted nanocarriers have been conjugated with magnetic probes, which demonstrated to be an effective dual targeting nanoplatform for the delivery of anticancer drugs by guiding the nanocarriers to cancer sites efficiently using an external magnetic field [32].…”

Section: Introductionmentioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

138

126

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Section: Introductionmentioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

138

126

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“…Some researchers used Franz cell dissolution apparatus or paddle apparatus (USP XXIII) to analyze the in vitro 5-FU release from polymeric nanoparticles (19,20). In addition, sampling from release medium at predetermined times and separating nanoparticles through centrifugation or ultrafiltration was used for assessing in vitro 5-FU release (21,22). Altogether, the variety of methods for tracking in vitro release profile of this model drug has made it impossible to make a reasonable comparison between various nanoparticulate systems.…”

Section: Introductionmentioning

confidence: 99%

5-Fluorouracil-Loaded BSA Nanoparticles: Formulation Optimization and In Vitro Release Study

2008

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Abstract. Over the past few decades, there has been considerable interest in developing protein nanoparticles as drug delivery devices. The underlying rationale is their exceptional characteristics, namely biodegradability and nonantigenicity. Herein, phase separation method was used to prepare 5-fluorouracil-loaded bovine serum albumin (BSA) nanoparticles. Drug release was tracked by continuous flow dialysis technique. Effect of process variables on loading efficiency of 5-fluorouracil was investigated and optimized through Taguchi's M16 design with the amount of entrapped drug as response. Optimum condition was found to be 2 mg/mL of 5-fluorouracil, 3.7 mL of added ethanol, 176 µL of glutaraldehyde, drug-protein incubation time of 30 min, and pH of 8.4 for 200 mg of BSA in 2 mL drug solution. pH had the most noticeable effect on the amount of entrapped drug, but glutaraldehyde had the least. Mean diameter and zeta potential of fabricated nanoparticles under these conditions were 210 nm and −31.7 mV, respectively. Drug-loaded BSA nanoparticles suspension maintained constant release of drug for 20 h under experimental conditions, so this colloidal drug carrier is capable of releasing drug in a sustained manner.

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“…In rats after intravenous administration this nanoparticle formulation showed a lower drug clearance than after the free drug administration [95]. In addition, poly(d,l-lactide)-g-poly(N-isopropyl acrylamide-comethacrylic acid) nanoparticles have been studied as drug carrier for intracellular delivery of 5-fluorouracil [96].…”

Section: Anti-metabolitesmentioning

confidence: 99%

Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

Serpe

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Cancer as Drug Delivery Target Nanoparticles as Anticancer Drug Delivery System Conventional Nanoparticles Sterically Stabilized Nanoparticles Actively Targetable Nanoparticles Routes of Drug Nanoparticles Administration Anticancer Drug Nanoparticles Anthracyclines Reverse of P‐glycoprotein Mediated Multidrug Resistance of Cancer Cells to Doxorubicin Antiestrogens Anti‐metabolites Camptothecins Cisplatin Paclitaxel Miscellaneous Agents Arsenic Trioxide Butyric Acid Cystatins Diethylenetriaminepentaacetic Acid Mitoxantrone Gene Therapy

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Preparation and characterization of intelligent core-shell nanoparticles based on poly(d,l-lactide)-g-poly(N-isopropyl acrylamide-co-methacrylic acid)

Cited by 155 publications

References 29 publications

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

5-Fluorouracil-Loaded BSA Nanoparticles: Formulation Optimization and In Vitro Release Study

Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

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