Preparation and characterization of itraconazole loaded nanomicelles based on dextran–behenic acid for cutaneous leishmaniasis treatment

Shahriyar, S. M.; Taymouri, Somayeh; Saberi, Sedigheh; Asadi, Parvin; Tabbakhian, Majid

doi:10.1080/03639045.2021.1890112

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Similarly, behenic acid-based nano micelles were prepared with dextran as the combination to deliver itraconazole as a drug. The nano micelles were used as anti-leishmaniasis for targeting the parasite (Shahriyar et al, 2021). The saturated fatty acid (C:16), the palmitic acid, selected as the lead molecule in the present study has been deeply investigated previously (Lee et al, 2009) as an antiviral agent.…”

Section: Discussionmentioning

confidence: 99%

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionmentioning

confidence: 99%

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

2024

Frontiers Research Topics

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“…This special structure and charge distribution endow calcin with the ability to penetrate the cell membrane and specifically bind to RyRs, causing partial opening of RyRs by long-lasting subconductance and actively releasing Ca 2+ from the SR [ 56 , 57 ]. Based on this characteristic, our previous research found that calcin only partially depletes the SR Ca 2+ , with a maximum release ratio of approximate 60 %, therby preventing excessive elevation of SR Ca 2+ under β adrenergic stress while maintaining normal cardiac excitation-contraction coupling and diastolic function under normal conditions [ 58 , 59 ]. By using the representatve calcin, Imperacalcin, we confirmed this hypothesis and found that it can antagonize SR Ca 2+ overload related tachyarrhythmias such as PVCs and non-sustained BVTs in CPVT [ 55 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

OpiCa1-PEG-PLGA nanomicelles antagonize acute heart failure induced by the cocktail of epinephrine and caffeine

Li,

Wang,

Liu

et al. 2023

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Investigation of bioactive compounds from Bacillus sp. against protein homologs CDC42 of Colletotrichum gloeosporioides causing anthracnose disease in cassava by using molecular docking and dynamics studies

Papathoti

Mendam

Kanduri³

et al. 2022

Front. Mol. Biosci.

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Manihot esculenta, commonly called cassava, is an economically valuable crop and important staple food, grown in tropical and subtropical regions of the world. Demand for cassava in the food and fuel industry is growing worldwide. However, anthracnose disease caused by Colletotrichum gloeosporioides severely affects cassava yield and production. The bioactive molecules from Bacillus are widely used to control fungal diseases in several plants. Therefore, in this study, bioactive compounds (erucamide, behenic acid, palmitic acid, phenylacetic acid, and β-sitosterol) from Bacillus megaterium were assessed against CDC42, a key protein for virulence, from C. gloeosporioides. Structure of the CDC42 protein was generated through the comparative homology modeling method. The binding site of the ligands and the stability of the complex were analyzed through docking and molecular dynamics simulation studies, respectively. Furthermore, a protein interaction network was envisaged through the STRING database, followed by enrichment analysis in the WebGestalt tool. From the enrichment analysis, it is apparent that bioactive from B. megaterium chiefly targets the MAP kinase pathway that is essential for filamentous growth and virulence. Further exploration through experimental studies could be advantageous for cassava improvement as well as to combat against C. gloeosporioides pathogen.

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Preparation and characterization of itraconazole loaded nanomicelles based on dextran–behenic acid for cutaneous leishmaniasis treatment

Cited by 4 publications

References 41 publications

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

Molecular Level Atomistic and Structural Insights on Biological Macromolecules, Inhibition, and Dynamics Studies

OpiCa1-PEG-PLGA nanomicelles antagonize acute heart failure induced by the cocktail of epinephrine and caffeine

Investigation of bioactive compounds from Bacillus sp. against protein homologs CDC42 of Colletotrichum gloeosporioides causing anthracnose disease in cassava by using molecular docking and dynamics studies

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