Preparation and characterization of metformin surface modified cellulose nanofiber gel and evaluation of its anti-metastatic potentials

Nurani, Maryam; Akbari, Vajihe; Taheri, Azade

doi:10.1016/j.carbpol.2017.02.067

Cited by 50 publications

(21 citation statements)

References 63 publications

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“…Below we provide (in addition to the paper [8]) a short summary of currently available data. The results of in vitro experiments suppose the ability of a gel-like structure composed of metformin molecules associated with cellulose nanofibers slow down the migration (and therefore metastasising and dissemination) of melanoblastoma cells [13]. Taking into account the data on lower colorectal cancer incidence in metformin-treated diabetic patients, there is a possibility of using fatty-(supposedly a better variant) or polyethylene glycol (PEG)-based suppositories at least in patients with colorectal adenomas with or without diabetes mellitus as an alternative to standard drug form [14].…”

Section: Potential Application Areasmentioning

confidence: 99%

Metformin: not only per os

Berstein¹

2018

Expert Review of Endocrinology & Metabolism

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Section: Potential Application Areasmentioning

confidence: 99%

Metformin: not only per os

Berstein¹

2018

Expert Review of Endocrinology & Metabolism

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“…Also, CNF was used to enhance puncture strength of films used in drug delivery for colon-related diseases [ 183 ]. The adhesion properties of the CNF were used for anti-metastatic and anti-cancer purposes [ 184 ]. Metformin (an anti-cancer drug) was loaded to the surface of nanocellulose (forming a Met-CNF gel structure) to restrict the migration, adhesion and invasion of melonoma cells once implanted around the tumor.…”

Section: Nanocellulose In Biomedical Applicationsmentioning

confidence: 99%

Cellulose Nanomaterials—Binding Properties and Applications: A Review

et al. 2018

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Cellulose nanomaterials (CNs) are of increasing interest due to their appealing inherent properties such as bio-degradability, high surface area, light weight, chirality and the ability to form effective hydrogen bonds across the cellulose chains or within other polymeric matrices. Extending CN self-assembly into multiphase polymer structures has led to useful end-results in a wide spectrum of products and countless innovative applications, for example, as reinforcing agent, emulsion stabilizer, barrier membrane and binder. In the current contribution, after a brief description of salient nanocellulose chemical structure features, its types and production methods, we move to recent advances in CN utilization as an ecofriendly binder in several disparate areas, namely formaldehyde-free hybrid composites and wood-based panels, papermaking/coating processes, and energy storage devices, as well as their potential applications in biomedical fields as a cost-effective and tissue-friendly binder for cartilage regeneration, wound healing and dental repair. The prospects of a wide range of hybrid materials that may be produced via nanocellulose is introduced in light of the unique behavior of cellulose once in nano dimensions. Furthermore, we implement some principles of colloidal and interfacial science to discuss the critical role of cellulose binding in the aforesaid fields. Even though the CN facets covered in this study by no means encompass the great amount of literature available, they may be regarded as the basis for future developments in the binder applications of these highly desirable materials.

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“…Moreover, nanofibers can act as cell-adhesive ECM. Based on these considerations, NFCs were prepared and tested for their anti-metastatic potential [ 112 ]. Due to the ability to form matrices, NFCs were also loaded with the anti-cancer and anti-metastatic drug metformin (Met).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

et al. 2017

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Because of its high biocompatibility, bio-degradability, low-cost and easy availability, cellulose finds application in disparate areas of research. Here we focus our attention on the most recent and attractive potential applications of cellulose in the biomedical field. We first describe the chemical/structural composition of cellulose fibers, the cellulose sources/features and cellulose chemical modifications employed to improve its properties. We then move to the description of cellulose potential applications in biomedicine. In this field, cellulose is most considered in recent research in the form of nano-sized particle, i.e., nanofiber cellulose (NFC) or cellulose nanocrystal (CNC). NFC is obtained from cellulose via chemical and mechanical methods. CNC can be obtained from macroscopic or microscopic forms of cellulose following strong acid hydrolysis. NFC and CNC are used for several reasons including the mechanical properties, the extended surface area and the low toxicity. Here we present some potential applications of nano-sized cellulose in the fields of wound healing, bone-cartilage regeneration, dental application and different human diseases including cancer. To witness the close proximity of nano-sized cellulose to the practical biomedical use, examples of recent clinical trials are also reported. Altogether, the described examples strongly support the enormous application potential of nano-sized cellulose in the biomedical field.

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Preparation and characterization of metformin surface modified cellulose nanofiber gel and evaluation of its anti-metastatic potentials

Cited by 50 publications

References 63 publications

Metformin: not only per os

Metformin: not only per os

Cellulose Nanomaterials—Binding Properties and Applications: A Review

Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

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