Preparation and Characterization of Nano-Lipopeptide Biosurfactant Hydrogel and Evaluation of Wound-Healing Properties

Afsharipour, Sepehr; Asadi, Alireza; Ohadi, Mandana; Ranjbar, Mehdi; Forootanfar, Hamid; Jafari, Elham; Dehghannoudeh, Gholamreza

doi:10.1007/s12668-021-00896-5

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Li et al (2007) [ 100 ] highlighted the importance of using angiogenesis in wound repair, making emphasis on growth factors and the role that those factors play on the extracellular matrix. Following that context, Afsharipour et al (2021) [ 101 ] assessed the impact of lipopeptides (LPBs) on angiogenesis. They observed that it triggered tube formation and promoted the migration of endothelial cells, marking significant progression in the angiogenesis process.…”

Section: Perspectives Of Biosurfactants For Wound-healing Anticancer ...mentioning

confidence: 99%

“…More recent studies displayed that it is not just the amphiphilic properties of LPB which play an important role on wound healing, but the size of the molecule within effective formulations in in vivo models. Afsharipour et al (2021) [101] have shown that it is possible to use a nano-lipopeptide biosurfactant (NLPB) formulation from LPB, highlighting the maximum efficacy at smaller sizes of LPBs. Lipopeptides are not the only type of biosurfactant that displays a positive effect on the treatment of wound healing.…”

Section: Wound Healingmentioning

confidence: 99%

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Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Section: Perspectives Of Biosurfactants For Wound-healing Anticancer ...mentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Li et al (2007) [100] highlighted the importance of using angiogenesis in wound repair, making emphasis on growth factors and the role that those factors play on the extracellular matrix. Following that context, Afsharipour et al (2021) [101] assessed the impact of lipopeptides (LPBs) on angiogenesis. They observed that it triggered tube formation and promoted the migration of endothelial cells, marking significant progression in the angiogenesis process.…”

Section: Wound Healingmentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Preprint

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability, and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal, and antiviral effects, antioxidant, anticancer, and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formation in clinical, hygiene, and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro and nanoemulsions, and hydrogels, improving drug solubility, stability, and bioavailability and enabling targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analyzing recent literature, this review aims to provide insights into the present understanding, highlight emerging trends, identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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“…The percentage of wound closure of mice treated with NLPB hydrogels at 2 mg/mL was approximately 80% on day 7 and 100% on day 15. The NLPB hydrogel formulation showed better efficacy in wound closure and healing when compared to the control [ 146 ].…”

Section: Biological Propertiesmentioning

confidence: 99%

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

Araújo

Monteiro

Silva³

et al. 2022

Antibiotics

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Surface-active compounds (SACs), biomolecules produced by bacteria, yeasts, and filamentous fungi, have interesting properties, such as the ability to interact with surfaces as well as hydrophobic or hydrophilic interfaces. Because of their advantages over other compounds, such as biodegradability, low toxicity, antimicrobial, and healing properties, SACs are attractive targets for research in various applications in medicine. As a result, a growing number of properties related to SAC production have been the subject of scientific research during the past decade, searching for potential future applications in biomedical, pharmaceutical, and therapeutic fields. This review aims to provide a comprehensive understanding of the potential of biosurfactants and emulsifiers as antimicrobials, modulators of virulence factors, anticancer agents, and wound healing agents in the field of biotechnology and biomedicine, to meet the increasing demand for safer medical and pharmacological therapies.

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Preparation and Characterization of Nano-Lipopeptide Biosurfactant Hydrogel and Evaluation of Wound-Healing Properties

Cited by 9 publications

References 26 publications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Surface-Active Compounds Produced by Microorganisms: Promising Molecules for the Development of Antimicrobial, Anti-Inflammatory, and Healing Agents

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