Preparation and characterization of nanofunctionalized alginate/methacrylated gelatin hybrid hydrogels

Kadri, R.; Messaoud, Ghazi Ben; Tamayol, Ali; Aliakbarian, Bahar; Zhang, H. Y.; Hasan, Mahmoud; Sánchez-González, Laura; Arab‐Tehrany, Elmira

doi:10.1039/c6ra03699f

Cited by 26 publications

(19 citation statements)

References 44 publications

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“…This tendency was confirmed after 8 h of incubation, and the rate of mass loss was approximately double (39.2% in GelMA-Nanoliposomes hydrogels against 21.0% and 18.3% in pure GelMA and GelMA-Emulsion hydrogels, respectively). This increase can be due to a physical phenomenon, as nanoliposomes incorporation increases pores size and enhances their distribution [ 29 ], which releases a way of privileged access to the collagenase, multiplying by twice the area of access sequences Arg-Gly-Asp (RGD), which are considered matrix metalloproteinase 2 (MMP-2) binding sites. These enzymes can degrade and remodel the extracellular matrix for cell spreading and migration.…”

Section: Resultsmentioning

confidence: 99%

“…can be optimized further by incorporating nanoparticles within the hydrogel. Previous works [ 29 , 30 ] showed that nanoliposomes improve mechanical properties and porosity of the GelMA hydrogels. In order to compare the various properties of GelMA functionalized with lipidic nanoparticles differing by their external surface hydrophilicity and their structure.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels

Rahali

Messaoud

Kahn

et al. 2017

IJMS

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Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Physicochemical and mechanical properties were improved by the incorporation of nanoparticles developed from two innovative fabrication processes: High shear fluid and low frequencies/high frequencies ultrasounds. Both rapeseed nanoliposomes and nanodroplets were successfully incorporated in the GelMA networks during the photo polymerization process. The impact on polymer microstructure was investigated by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and enzymatic degradation investigations. Mechanical stability and viscoelastic tests were conducted to demonstrate the beneficial effect of the functionalization on GelMA hydrogels. Adding nanoparticles to GelMA improved the surface properties (porosity), tuned swelling, and degradability properties. In addition, we observed that nanoemulsion didn’t change significantly the mechanical properties to shear and compression solicitations, whereas nanoliposome addition decreased Young’s modulus under compression solicitations. Thus, these ways of functionalization allow controlling the design of the material by choosing the type of nanoparticle (nanoliposome or nanoemulsion) in function of the application.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels

Rahali

Messaoud

Kahn

et al. 2017

IJMS

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“…Phospholipids are amphiphilic molecules composed of a hydrophilic head and a hydrophobic tail. Their amphiphilic property allows the self-sealing of liposomes, which renders them an ideal delivery system in aqueous media and has various applications in the cosmetic [30], food [31], pharmaceutical [32], and tissue engineering [33,34] fields.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments

et al. 2019

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Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.

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“…Rahali et al functionalized GelMA hydrogels with naturally derived nanoliposomes and reported that the incorporation of nanoliposomes enhanced the mechanical stability of the functionalized GelMA hydrogels; proven by their higher resistance to twist and shear . Similarly, it was also demonstrated that the incorporation of nanoliposomes within alginate/GelMA hydrogels affected the rheological properties of the formed hydrogels, as well as their mechanical properties . This observation was related to the ability of the alginate–gelatin mixture to tune the mechanical properties of refined architectures.…”

Section: Properties Of Soft Nanoparticle–functionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

110

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Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

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Preparation and characterization of nanofunctionalized alginate/methacrylated gelatin hybrid hydrogels

Abstract: We developed the preparation of alginate/methacrylated gelatin (GelMA) hybrid hydrogels functionalized with nanoliposomes encapsulating curcumin.

Cited by 26 publications

References 44 publications

Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels

Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels

Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

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