Preparation And Characterization Of Nimesulide Nanoparticles For Dissolution Improvement

Abstract

Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low solubility in water that leads to decrease in dissolution rate. So the objective of this study was to decrease particle size, increase solubility and dissolution rate of nimesulide by preparation of nimesulide nanoparticles using solvent/antisolvent precipitation method by addition of organic solution of drug onto the solution of stabilizer. The size of nimesulide nanoparticles were studied and considered by particle size analyzer, drug content and loading efficiency. The freeze dried nanoparticles were characterized by field emission electron microscope, X-Ray powder diffraction, differential scanning calorimetry and saturated solubility measurement. Tablet was manufactured by direct compression. The tablets were evaluated for drug release to measure the effect of nanoparticles on the dissolution improvement of drug.

Cefotaxime Eluting Niosomes as A Novel Approach to Potentiate the Antibacterial Activity

“…The other functional groupings don't hold up very well. The ingredients used in the medicine's recipe did not have any negative interactions with the drug (CN6), and the formula was consequently allowed to undergo additional testing (Figure 5) [28]. The compounds span 60, tween 40, and cholesterol have numerous polar groups (C═O, OH, and NH3+) in each molecule that may be involved in intra Hbonding; thus, no chance for inter H-bonding with the drug.…”