Preparation and characterization of novel functionalized multiwalled carbon nanotubes/chitosan/β-Glycerophosphate scaffolds for bone tissue engineering

Gholizadeh, Shayan; Moztarzadeh, Fathollah; Haghighipour, Nooshin; Ghazizadeh, Leila; Baghbani, Fatemeh; Shokrgozar, Mohammad Ali; Allahyari, Zahra

doi:10.1016/j.ijbiomac.2016.12.086

Cited by 105 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, most of the studies on biological applications of CNTs-based and other carbon allotropes (graphene, fullerene) as biomaterials are focused on an approach to continuous interactions with living cells and tissues [17]. However, it has also been reported that cell/tissue interactions with CNTs can have adverse effects, which can cause a potential risk to human health [17]. Herein, we briefly described the synthesis and applications of carbon-derived nanomaterials in agricultural and biotechnological fields.…”

Section: Single Layer Of Graphene Multiple Layer Of Graphene Expensivementioning

confidence: 99%

“…The high-quality CNTs can be produced through this approach by using the suitable catalyst and optimizing the process conditions [20,21]. The pressure of the gas and the applied current in the Various reports are available that emphasize the significance of CNTs to support bone growth by enhancing the mechanical properties of existing natural and synthetic polymers [16,17]. Currently, most of the studies on biological applications of CNTs-based and other carbon allotropes (graphene, fullerene) as biomaterials are focused on an approach to continuous interactions with living cells and tissues [17].…”

Section: Arc Dischargementioning

confidence: 99%

“…The pressure of the gas and the applied current in the Various reports are available that emphasize the significance of CNTs to support bone growth by enhancing the mechanical properties of existing natural and synthetic polymers [16,17]. Currently, most of the studies on biological applications of CNTs-based and other carbon allotropes (graphene, fullerene) as biomaterials are focused on an approach to continuous interactions with living cells and tissues [17]. However, it has also been reported that cell/tissue interactions with CNTs can have adverse effects, which can cause a potential risk to human health [17].…”

Section: Arc Dischargementioning

confidence: 99%

See 2 more Smart Citations

Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications

et al. 2020

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) are considered a promising nanomaterial for diverse applications owing to their attractive physicochemical properties such as high surface area, superior mechanical and thermal strength, electrochemical activity, and so on. Different techniques like arc discharge, laser vaporization, chemical vapor deposition (CVD), and vapor phase growth are explored for the synthesis of CNTs. Each technique has advantages and disadvantages. The physicochemical properties of the synthesized CNTs are profoundly affected by the techniques used in the synthesis process. Here, we briefly described the standard methods applied in the synthesis of CNTs and their use in the agricultural and biotechnological fields. Notably, better seed germination or plant growth was noted in the presence of CNTs than the control. However, the exact mechanism of action is still unclear. Significant improvements in the electrochemical performances have been observed in CNTs-doped electrodes than those of pure. CNTs or their derivatives are also utilized in wastewater treatment. The high surface area and the presence of different functional groups in the functionalized CNTs facilitate the better adsorption of toxic metal ions or other chemical moieties. CNTs or their derivatives can be applied for the storage of hydrogen as an energy source. It has been observed that the temperature widely influences the hydrogen storage ability of CNTs. This review paper highlighted some recent development on electrochemical platforms over single-walled CNTs (SWCNTs), multi-walled CNTs (MWCNTs), and nanocomposites as a promising biomaterial in the field of agriculture and biotechnology. It is possible to tune the properties of carbon-based nanomaterials by functionalization of their structure to use as an engineering toolkit for different applications, including agricultural and biotechnological fields.

show abstract

Section: Single Layer Of Graphene Multiple Layer Of Graphene Expensivementioning

confidence: 99%

Section: Arc Dischargementioning

confidence: 99%

Section: Arc Dischargementioning

confidence: 99%

See 1 more Smart Citation

Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Bone tissue engineering has emerged in recent years as a potential approach to overcome the difficulties in healing, regeneration and functional restoration of bone defects following damages caused by trauma or as a result of osteoporosis amongst other relevant causes [1][2][3]. This approach is usually accompanied by the combination of a synthetic, natural or hybrid 2D or 3D scaffolds, cells, and a physiologically relevant chemical or physical signaling [4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications

Nekounam

Gholizadeh

Allahyari

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Bone tissue engineering is a new and applicable emerging approach to repair the bone defects. In this regard, designing and robust fabrication of tissue engineering scaffolds that could provide an appropriate environment for cell proliferation and differentiation is of high interest.Electrical conductive scaffolds which provide a substrate for stimulating cell growth and differentiation through a physiologically relevant physical signaling, electrical stimulation, has shown a highly promise in this approach. In this paper, we fabricated carbon nanofiber/gold nanoparticle (CNF/GNP) conductive scaffolds using two distinct methods; blending electrospinning in which gold nanoparticles were blended with electrospinning solution and electrospun, and electrospinning/electrospraying in which gold nanoparticle was electrosprayed simultaneously with electrospinning. The obtained electrospun mats underwent stabilization/carbonization process to prepare CNF/GNP scaffolds. The scaffolds were characterized by SEM, XRD, and Raman spectroscopy. SEM characterizations showed improved morphology and a slight decrease in the diameter of the spinned and sprayed nanofibers with moderate concentrations (from 178.66 ± 38.40 nm to 157.94 ± 24.14 nm and 120.81 ± 13.77 nm, respectively), In the electrosprayed form, better size distributions of nanofibers and less adhesion between individual fibers was observed, while XRD analysis confirmed the crystal structure of the nanofibers. Raman spectroscopy revealed enhancement in the graphitization of the structure, and the electrical conductivity of the structure improved by up to 29.2% and 81% in electrospraying and blending electrospinning modes, respectively. Indirect MTT and LDH toxicity assays directly were performed to assess MG63 cell toxicity, but no significant toxicity was observed and the scaffolds did not adversely affect cell proliferation.Overall, it can be concluded that in early tests, this structure have significant potential for bone tissue engineering applications.

show abstract

“…MWCNTs in CS/β-Glycerophosphate nanocomposites have increased the alkaline phosphatase activity in comparison to neat CS. 32 Another important aspect of the use of MWCNTs for biomedical applications is the cytotoxicity they can cause to surrounding tissue. It has been proven that concentrations from 0.8-10μg/ml exposed to epithelial cells for 24 and 48h were non-toxic.…”

mentioning

confidence: 99%

Nanotubes Reinforcement of Degradable Polymers for Orthopedic Applications

Kozaniti

Papanikolaki

Theofanis

et al. 2017

ATROA

View full text Add to dashboard Cite

Biodegradable polymers have been studied as scaffolds for bone tissue engineering applications. However, they possess insufficient mechanical properties to be considered as alternatives at sites of increased mechanical loading. To improve their mechanical properties, reinforcing with nanotubes has been investigated, as they reproduce the structure and length scale of bone native topography. The research advances in the use of nanotubes as reinforcing agents in developing nanocomposites with synthetic and natural biodegradable polymers are reviewed. The extent of mechanical reinforcement of the polymers and the corresponding biological response of the nanocomposites are presented.

show abstract

Preparation and characterization of novel functionalized multiwalled carbon nanotubes/chitosan/β-Glycerophosphate scaffolds for bone tissue engineering

Cited by 105 publications

References 36 publications

Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications

Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications

Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications

Nanotubes Reinforcement of Degradable Polymers for Orthopedic Applications

Contact Info

Product

Resources

About