Preparation and Characterization of Novel Poly(alkylidenamine) Nitrile Ruthenium Metallodendrimers

Abstract

] [dppe = 1,2-bis(diphenylphosphanyl)ethane] was attained with good yield, respectively, by treating the metallofragment with the core in methanol (at room temperature and in presence of TlPF 6 as a chloride abstractor) and in 1,2-

Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells

“…Two low generation poly(alkylidenimine) dendrimer cores having nitrile groups at their periphery and distinct in size and flexibility ( Scheme 1 , dendrimers 1 and 2 ) were used to prepare two different [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 ] + functionalized poly(alkylidenimine) dendrimers ( Scheme 1 , metallodendrimers 3 and 4 ). The synthesis followed a methodology previously developed by our group [ 83 ]. However, because the use of thallium compounds may result in unwanted cytotoxicity, thus hampering the results, in the current work, the prepared compounds were synthesized using a slight modification of the original procedure.…”

“…All reactions and manipulations involved in the preparation of the dendrimers [N≡C(CH 2 ) 2 ] 2 N(CH 2 ) 6 N[(CH 2 ) 2 C≡N] 2 ( 1 ) and [N≡C(CH 2 ) 2 O(CH 2 ) 3 ] 2 N(CH 2 ) 6 N[(CH 2 ) 3 O(CH 2 ) 2 C≡N] 2 ( 2 ), and the metallodendrimers 3 and 4 were executed under a dry nitrogen atmosphere by applying standard Schlenk-tube techniques. The starting materials [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 Cl] [ 91 ] and the dendrimers 1 and 2 were prepared by following published methods [ 83 ].…”

Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers

“…. 33 With this result, we realized that the formation of the tetracoordinate product starting from (1) and using cis-[RuCl(dppe) 2 ][PF 6 ] was prevented probably due to steric hindrance of the bulky metallofragment at the periphery. 23,34 The preparation of compound (2) represented the first example of application of nitrile-fuctionalized poly-(alkylidenamine) on the preparation of stable cationic metallodendrimers (Generation 0) and a novel quantitative method to solidify and chromatographically purify the otherwise amorphous or semi-liquid nitrile-functionalized poly(alkylidenamine) dendrimers.…”

Synthetic polyamines promote rapid lamellipodial growth by regulating actin dynamics

“…The procedure for the preparation of branched polynitriles was the following 36 : acrylonitrile (5.0 equiv.) was added dropwise to the corresponding diamine (1.0 eq) dissolved in H 2 O at room temperature (RT).…”