Preparation and characterization of novel β-chitin–hydroxyapatite composite membranes for tissue engineering applications

Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests

“…This mineral can be regarded, with some limitations, as a crystallochemical analogue of the main mineral constituent of human and animal skeletal tissues [6]. A wide range of biomaterials for different clinical applications can be created on the basis of two components: nanocrystalline apatite and chitosan [3][4][5][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Chitin is the second (after cellulose) most abundant natural polysaccharide.…”

“…Most of them involve two major stages: first, synthesis of the organic polymeric scaffolds of pure or chemically treated and modified chitosan; and second, mineralization of the scaffold in the simulated body fluid (the biomimetic way) or in saturated matrix solutions [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The scaffolds can be made in the form of membranes, microspheres [27] or multilayered materials.…”

“…Porous specimens were osteoconducting and were replaced in vivo by newly formed bone tissue. Keywords: biodegradation, chitosan, hydroxyapatite, osteogenesis, scaffolds [11,14]; chitin can also be used as a scaffold [13,22]. An inverse approach has also been described, viz., preformation of a porous hydroxyapatite scaffold followed by its impregnation with chitosan [8].…”

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

“…Tissue engineering developed with the idea of using biomaterials and cells to help tissues repair themselves [1][2][3]. As this branch of science developed further, its aim changed toward the development of rational strategies in order to optimize formation of new tissues to nally induce the formation of new tissues or organs [4].…”

Novel Chitin and Chitosan Materials in Wound Dressing

“…It helps in faster wound healing and scar prevention (Paul & Sharma, 2004). The advantage of chitin and chitosan is easily can processed into hydrogels (Nagahama et al, 2008a;Nagahama et al, 2008b;Tamura et al, 2010), membranes (Yosof, Wee, Lim & Khor, 2003;Marreco et al, 2004;Jayakumar et al, 2007;Jayakumar et al, 2008Madhumathi et al, 2009), nanofibers ( Shalumon et al, 2009;Shalumon et al, 2010;, beads (Yosof, Lim & Khor, 2001;Jayakumar et al, 2006), micro/nanoparticles Prabaharan, 2008;Anitha et al, 2009;Anitha et al, 2010;Dev et al, 2010), scaffolds (Peter et al, 2009;Peter et al, 2010;Prabaharan & Jayakumar, 2009;Maeda et al, 2008) and sponges (Muramatsu, Masuda, Yoshihara & Fujisawa, 2003;Portero, 2007) for various types of biomedical applications such as drug and gene delivery Jayakumar et al, 2010a), wound healing (Jayakumar et al, 2005;Jayakumar et al, 2007;Jayakumar et al, 2010b;Jayakumar et al, 2010c;Tamura et al, 2010) and tissue engineering (Jayakumar et al, 2005;Jayakumar et al, 2010d;Tamura et al, 2010). Various forms of wound dressings materials based on chitin and chitosan derivatives are commercially available.…”