Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis

Singh, Vinay Kumar; Anis, Arfat; Banerjee, Indranil; Pramanik, Krishna; Bhattacharya, Mrinal; Pal, Kunal

doi:10.1016/j.msec.2014.08.026

Cited by 131 publications

(110 citation statements)

References 44 publications

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“…Bigels were packed in tightly closed plastic containers and stored at 30 ± 2 °С/65 ± 5 % RH for 6 months [17]. Their physical stability was evaluated through observation for any change in color, phase separation, or syneresis at regular time intervals [5,18]. To assess changes in their microarchitecture during storage, they were subjected to optical microscopy, as described above.…”

Section: Stability Study Of the Bigel Formulationsmentioning

confidence: 99%

“…Samples with a volume of 3 mL were analyzed at 25.0 ± 0.5 °C. The measurements were performed three times and the results were recorded as the mean ± standard deviation (SD) [5].…”

Section: Droplet Size Distributionmentioning

confidence: 99%

“…Olive oil [2], sesame oil [4,5], sunflower oil [6], soybean oil [1,7] and fish oil [8,9] are the most commonly used oils for bigel preparation. Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Sorbitan monostearate (Span® 60, SMS, hydrophilic-lipophilic balance value 4.7) is a hydrophobic nonionic surfactant used in pharmaceutical formulations as a water-in-oil emulsifying agent. This compound gels several organic solvents, as well as a range of vegetable oils [4,5,12]. The aim of this study was to obtain and evaluate carbopol hydrogel/SMS-almond oil based organogel biphasic formulations (bigels) as a vehicle for semi-solid drug formulations with a topical application.…”

Section: Introductionmentioning

confidence: 99%

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Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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Section: Stability Study Of the Bigel Formulationsmentioning

confidence: 99%

“…Samples with a volume of 3 mL were analyzed at 25.0 ± 0.5 °C. The measurements were performed three times and the results were recorded as the mean ± standard deviation (SD) [5].…”

Section: Droplet Size Distributionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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Influence of Aqueous Matrices into Candelilla Wax Organogels Emulsions for Topical Applications

Botega

Nogueira

Moura

et al. 2020

J Americ Oil Chem Soc

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Emulgels and bigels are, respectively, partial and total gelified forms of emulsions that can increase stability and bring different permeation and diffusion properties for traditional oil and water mixtures. This work investigated the stability, rheological behavior, and microstructure of bigels and emulgels through a topical application perspective. Candelilla wax (CW)/sunflower oil (5/95) organogels or pure sunflower oil was used to obtain dilute (5% oily phase) and concentrated (40% oily phase) emulsions. It was used three different aqueous phases with each oily phase and oil load: water, sodium polyacrylate hydrogel, and modified starch hydrogel. Dilute emulsions showed better stability with sodium polyacrylate hydrogel forming oil‐in‐water bigels and emulgels while concentrated emulsions were stable only in water‐in‐oil emulgels. Thixotropy, network strength, and thermal stability were modulated by the oily phase and concentration used. Concentrated emulgels showed higher spreadability, but strong temperature‐dependency. Diluted emulgels and bigels showed high hydrogel influence on stability and rheological properties observed. The results showed the potential of CW organogels to stabilize and modify sensory attributes in bigels and emulgels for topical applications.

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Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis

Cited by 131 publications

References 44 publications

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Influence of Aqueous Matrices into Candelilla Wax Organogels Emulsions for Topical Applications

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