Preparation and characterization of PEG-cross-linked chitosan hydrogel films with controllable swelling and enzymatic degradation behavior

Tanuma, Hideki; Saitō, Takashi; Nishikawa, Ken‐Ichi; Dong, Tungalag; Yazawa, Koji; Inoue, Yoshio

doi:10.1016/j.carbpol.2009.11.022

Cited by 99 publications

(58 citation statements)

References 22 publications

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“…CTS-grafted-mPEG (CTS-mPEG) was synthesized by utilizing PNC as a cross-linking agent, as previously reported, with modification [22,23]. Briefly, 0.8 g mPEG was melted under vacuum at 65°C, followed by adding 0.05 g PNC under constant stirring for 6 h, and the temperature was then cooled down to 40°C.…”

Section: Preparation Of Cts-mpegmentioning

confidence: 99%

Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Hoang

Tran

Trân

et al. 2016

Green Processing and Synthesis

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In this report, magnetic Fe 3 O 4 nanoparticles were functionalized with chitosan-grafted-poly(ethylene glycol) methyl ether (CTS-mPEG) for paclitaxel (PTX) delivery. The Fe 3 O 4 nanoparticles were prepared via the chemical coprecipitation method and then coated with CTS-mPEG (Fe 3 O 4 @CTS-mPEG) by a simple method. The formation of Fe 3 O 4 @CTS-mPEG was characterized by several methods including proton nuclear magnetic resonance spectroscopy, Fourier transform infrared, and X-ray diffraction. Furthermore, the superparamagnetic properties of Fe 3 O 4 @CTS-mPEG were demonstrated by a vibrating sample magnetometer; the saturation magnetization reached 23 emu g -1 . The sizes and morphologies of Fe 3 O 4 and Fe 3 O 4 @CTS-mPEG nanoparticles were determined by transmission electron microscopy. The result indicated that Fe 3 O 4 @CTS-mPEGs were nearly spherical in shape with an average diameter of 20 nm, compared with the 12-nm Fe 3 O 4 particles. Especially, PTX was effectively loaded into the coated nanoparticles, 86.9±3.4% for drug loading efficiency, and slowly released up to 120 h. These results suggest the potential applications of Fe 3 O 4 @CTS-mPEG in the development of stable drug delivery systems for cancer treatment.

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Section: Preparation Of Cts-mpegmentioning

confidence: 99%

Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Hoang

Tran

Trân

et al. 2016

Green Processing and Synthesis

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“…The pure CS film has an AWCA about 77.6 ± 3.6°, which is acceptable and in a good agreement with previous reports. There are literatures reported that the water contact angles of chitosan are 80 ± 4.6° [35], 60.7 ± 1.25° [36], 69.4° [ 37], 85.6° [38], and 84.54° [39]. We believed that the variation in water contact angle values of chitosan is due to non-equilibrium state of the testing and the swelling of materials.…”

Section: Surface Characterizationmentioning

confidence: 87%

Photosensitive chitosan to control cell attachment

Cheng

Cao

2011

Journal of Colloid and Interface Science

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“…Among the natural polymer‐based biodegradable hydrogels, chitosan (CS) hydrogel has more promising attention because of its biodegradable, noncarcinogenic, nonimmunogenic, and biocompatible features . Furthermore, the controllable swelling and enzymatic degradation qualities of CS hydrogel films have been improved by cross‐linking with polyethylene glycol (PEG) . The controlled drug releasing efficacy of the hydrogel depends upon the environmental stimuli such as pH, temperature, and magnetic field .…”

Section: Introductionmentioning

confidence: 99%

Magnetic iron oxide nanoparticles (MIONs) cross‐linked natural polymer‐based hybrid gel beads: Controlled nano anti‐TB drug delivery application

Kesavan¹,

Ayyanaar²,

Vijayakumar

et al. 2017

J Biomedical Materials Res

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The nanosized rifampicin (RIF) has been prepared to increase the solubility in aqueous solution, which leads to remarkable enhancement of its bioavailability and their convenient delivery system studied by newly produced nontoxic, biodegradable magnetic iron oxide nanoparticles (MIONs) cross-linked polyethylene glycol hybrid chitosan (mCS-PEG) gel beads. The functionalization of both nano RIF and mCS-PEG gel beads were studied using various spectroscopic and microscopic techniques. The size of prepared nano RIF was found to be 70.20 ± 3.50 nm. The mechanical stability and swelling ratio of the magnetic gel beads increased by the addition of PEG with a maximum swelling ratio of 38.67 ± 0.29 g/g. Interestingly, this magnetic gel bead has dual responsive assets in the nano drug delivery application (pH and the magnetic field). As we expected, magnetic gel beads show higher nano drug releasing efficacy at acidic medium (pH = 5.0) with maximum efficiency of 71.00 ± 0.87%. This efficacy may also be tuned by altering the external magnetic field and the weight percentage (wt%) of PEG. These results suggest that such a dual responsive magnetic gel beads can be used as a potential system in the nano drug delivery applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1039-1050, 2018.

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Preparation and characterization of PEG-cross-linked chitosan hydrogel films with controllable swelling and enzymatic degradation behavior

Cited by 99 publications

References 22 publications

Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Photosensitive chitosan to control cell attachment

Magnetic iron oxide nanoparticles (MIONs) cross‐linked natural polymer‐based hybrid gel beads: Controlled nano anti‐TB drug delivery application

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Preparation and characterization of PEG-cross-linked chitosan hydrogel films with controllable swelling and enzymatic degradation behavior

Cited by 99 publications

References 22 publications

Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Photosensitive chitosan to control cell attachment

Magnetic iron oxide nanoparticles (MIONs) cross‐linked natural polymer‐based hybrid gel beads: Controlled nano anti‐TB drug delivery application

Contact Info

Product

Resources

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Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Functionalization of Fe₃O₄ nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery