“…The short half-life problem, as well as side symptoms such as diarrhea, muscle cramps, vertigo, sleeplessness, rhinitis, dry cough, elevated blood potassium, and libido has necessitated the development of an alternate dosage form; whether reduce the frequency of dose or improve the drug's efficacy ( Mokale et al, 2014 ). Strategies such as prolonged release formulations of lowering the drug's hepatic metabolism might be useful in increasing the efficiency of a medicine using smaller amounts ( Kommana et al, 2020 , Hameed et al, 2021 ).…”