Preparation and characterization of phloretin by complexation with cyclodextrins

Abstract

RP and DPPH scavenging activity tests revealed that the antioxidant activity of phloretin improved after the formation of inclusion complexes.

Addressing the Exigent Role of a Coumarin Fluorophore toward Finding the Suitable Microenvironment of Biomimicking and Biomolecular Systems: Steering to Project the Drug Designing and Drug Delivery Study

“…CD molecules are widely used as a molecular container in the pharmaceutical industry, biochemistry, material chemistry, catalysis, and electronics with proficient entrapment of the ligand/drug molecule having comparable sizes forming host–guest supramolecular complexes, which are the mimicking model of the enzyme/protein–ligand/drug complexes. 29 , 30 , 32 , 42 , 43 , 46 − 50 CD molecules have the ability to alter the physical, chemical, and biological properties of guest molecules through the formation of inclusion complexes by capturing suitable hydrophobic guests into the hydrophobic cavity in aqueous media without forming a covalent bond. 32 , 46 , 47 , 49 , 51 Generally, CDs are α, β, and γ types containing 6, 7, and 8 glucopyranose units, respectively.…”

“… 29 , 30 , 32 , 42 , 43 , 46 − 50 CD molecules have the ability to alter the physical, chemical, and biological properties of guest molecules through the formation of inclusion complexes by capturing suitable hydrophobic guests into the hydrophobic cavity in aqueous media without forming a covalent bond. 32 , 46 , 47 , 49 , 51 Generally, CDs are α, β, and γ types containing 6, 7, and 8 glucopyranose units, respectively. The CD molecules have an internal cavity accessible to the guest molecules of proper dimension through an opening of 4.5–5.3, 6.0–7.0, and 7.5–8.5 Å for α-CD, β-CD, and γ-CD, respectively; the depths of all remaining are more or less the same (7.9 Å).…”

“…The CD molecules have an internal cavity accessible to the guest molecules of proper dimension through an opening of 4.5–5.3, 6.0–7.0, and 7.5–8.5 Å for α-CD, β-CD, and γ-CD, respectively; the depths of all remaining are more or less the same (7.9 Å). 32 , 46 , 47 , 49 , 51 The hydrophobic cavity with a constrained environment directs one probe or ligand molecule to form encapsulated complexes with a proper geometry inside the microenvironment of the CD cavity. 32 , 46 , 47 , 49 , 51 Such investigations in present day research exploiting photophysical aspects have gained interest to sense the various photoprocesses with exact mechanism 32 , 46 , 47 , 49 , 51 like excited--state proton transfer, 32 intramolecular charge transfer, and so on.…”

Sunscreens Containing Cyclodextrin Inclusion Complexes for Enhanced Efficiency: A Strategy for Skin Cancer Prevention

“…Different methods are used to prepare drug–CDs inclusion complexes, including co-precipitation, freeze drying, ball milling, and kneading [ 66 , 67 ]. The preparation method could affect the characteristics of the resulting inclusion complex [ 68 ].…”

Optimization of Ultrasound-Assisted Extraction of Phloretin and Other Phenolic Compounds from Apple Tree Leaves (Malus domestica Borkh.) and Comparison of Different Cultivars from Estonia

“…The effects of polyphenols on human health make these compounds prospective components in the production of functional foods [ 7 ]. Besides the enrichment of food products, these compounds are also used in practical healthcare for the production of dietary supplements and cosmetic preparations [ 8 ], e.g., phloretin as a natural skin whitening agent due to its ability to inhibit tyrosinase activity [ 9 ]. In experimental cell models, the antioxidant effect of phloretin towards different stressors has been reported already at concentrations of 0.27 μg/mL [ 10 ].…”