Preparation and characterization of phosphate-stabilized amorphous calcium carbonate nanoparticles and their application in curcumin delivery

Calcium carbonate: controlled synthesis, surface functionalization, and nanostructured materials

“…The preparation of ACC with distinct properties is affected by the mixing of reactants and additives, 60,61 the control of emulsion formation, 62 precipitation, and other parameters such as humidity, temperature, and pressure. 63 Therein, much attention has been paid to understanding the role of additives, such as magnesium, 64 phosphorus ions, 65 polymeric compounds, 66 and, in particular, the inclusion of carboxyl-containing compounds [67][68][69] in the stabilization of ACC. Meanwhile, the latest studies have indicated that ACC can be used to prepare organic-inorganic hydrogels 70 and films.…”

“…372 Moreover, PO 4 3À ions reduce particle nucleation and growth rate by binding to a crystal nucleus, thus effectively inhibiting the further crystallization of ACC. 65 The role of OH À ions in the ACC stabilizer is negligible when they are added after the precipitation of ACC as OH À ions are not able to alter the surface of the ACC NPs due to the ion association between Ca 2+ and CO 3 2À being much stronger than that between Ca 2+ and OH À . However, when OH À ions are incorporated in the bulk of ACC NPs rather than adsorbing on their surface, they have a remarkable influence on particle size.…”

“…414 Therefore, overcoming the high instability of ACC is the key to unlocking its applications in biological systems. 65 To overcome these limitations, Zhao et al 39 developed an ACC–DOX@silica nanoreactor (Fig. 35), which was obtained via the self-assembly of an ACC–DOX core surface coated with a silica shell (Fig.…”

In vitro study of curcumin calcium carbonate phosphate nanoparticles (Curcumin-NPs) impacts on the meriz goat’s coccidian oocysts

“…CaCO3 nanoparticles were provided from a local chemical store, and the amorphous phase was prepared according to Rao et al (12,25). Briefly, the aqueous solutions of CaCl2, NaCO3, Na2HPO4.12H2O) with deionized distilled water 100 ml were used for each.…”

“…were used). The screening was done as described above for both pH and temperature with the aid of a spectrophotometer according to protocols used in previous studies (12,25).…”