Preparation and characterization of poly(2‐methacryloyloxyethyl phosphorylcholine)‐block‐poly(D,L‐lactide) polymer nanoparticles

Abstract

A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1 H NMR, atomic force microscopy, and f-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)block-poly(D,L-lactide).

Self‐assembly and degradation of poly[(2‐methacryloyloxyethyl phosphorylcholine)‐block‐(D,L‐lactide)] diblock copolymers: large compound micelles to vesicles

“…On injecting a solution of polymer in an organic solvent into an aqueous phase, the PMPC‐ b ‐PLA copolymers spontaneously aggregate into well‐defined vesicles and LCMs. Although there has been a report of PMPC‐ b ‐PLA micelles,28 to our best knowledge, vesicles and LCMs are reported for the first time in the present paper. The degradation of the LCMs was also investigated.…”

“…The PMPC‐ b ‐PLA diblock copolymers used in this study (Table 1) were synthesized by atom transfer radical polymerization (ATRP) of MPC monomer using PLA‐Br as macroinitiator. The details of the synthesis procedure can be found elsewhere 28. The number average molecular weights of MPC and PLA‐Br used in this study were 300 and 3000 g mol −1 , which were determined using 1 H NMR analysis.…”

“…In the work reported here, we synthesized poly[(2‐methacryloyloxyethyl phosphorylcholine)‐ block ‐( D , L ‐lactide)] (PMPC‐ b ‐PLA) diblock copolymers with various hydrophilic PMPC weight fractions ( f PC ). Similar to PEO, PMPC is another biocompatible hydrophilic block with biomimetic membrane structure and PMPC‐based nanoparticles have shown excellent cytocompatibility 23–31. On injecting a solution of polymer in an organic solvent into an aqueous phase, the PMPC‐ b ‐PLA copolymers spontaneously aggregate into well‐defined vesicles and LCMs.…”

ATRP in the design of functional materials for biomedical applications

“…These copolymers have potential for the use in pharmaceutical and biomedical applications as sutures, implants for bone fixation, drug delivery systems, and tissue engineering scaffolds [105,107,111]. ATRP has been utilized to prepare well-defined polyester-based amphiphilic block copolymers with hydrophilic poly(meth)acrylates, including poly(2-methacryloyloxyetheyl phosphorylcholine) [112], poly( N , N -dimethylaminoethyl methacrylate) (PDMAEMA) [113–115], and PHEMA [116]. …”

Exothermic Behavior of Cyanine Dye-Containing Polymer Micelle Irradiated by Near Infrared (NIR) in Water

“…5.41×104 g / mol] をエタノール (8.02 mL) に溶解して 60°C で一晩かくはんした後，水に対して室温で 3 日間透析 した．食塩水を加えてポリマー濃度 (C p ) が 0.10 g / L の…”