Preparation and Characterization of Poly(D,L‐Lactide) (PLA) and Poly(D,L‐Lactide)‐Poly(Ethylene Glycol) (PLA‐PEG) Nanocapsules Containing Antitumoral Agent Methotrexate

Abstract

Summary: The aims of the present work were to prepare and characterize nanocapsules containing antitumoral agent methotrexate (MTX) from poly(D,L‐lactide) (PLA) and poly(D,L‐lactide)‐poly(ethylene glycol) diblock copolymer (PLA‐PEG) with the purpose of administrating this drug by topical ocular route for primary ocular lymphoma treatment. Nanocapsules were prepared by the interfacial deposition of preformed polymer. The influences of the initial amount of MTX on the encapsulation efficiency, drug recovery and drug content, as well as the physicochemical properties of the particles were evaluated. The particle mean diameters were 246 and 146 nm, and zeta potential values were −38.8 and −33.6 mV, for the MTX‐loaded nanocapsules prepared from PLA and PLA‐PEG, respectively. The methotrexate content in the particles increased with the increasing in the drug amount added to the formulations, but the drug recovery decreased significantly. After 4 h of in vitro release, 28 and 86% of MTX was released from PLA and PLA‐PEG nanocapsules, respectively.

Comportamento biológico de matriz scaffold acrescida de células progenitoras na reparação óssea

“…Alguns materiais poliméricos como o ácido polilático e o ácido poli-glicólico (FARIA et al, 2005) ou os co-polímeros podem ser utilizados como scaffolds para promover a regeneração óssea (CAMILO et al, 2006), proporcionando mínima inflamação ao redor do implante e osteointegração em perdas ósseas (BOLSON et al, 2005). No entanto, a maior limitação desses materiais porosos à base de polímeros está em sua relativa baixa elasticidade e resistência mecânica não-compatível a aplicações em regiões articulares e substituições ósseas (CAPK et al, 1990;GRIFFITH, 2000).…”

Half‐Life Extension with Pharmaceutical Formulations: Nanoparticles by the Miniemulsion Process

“…By interfacial deposition of the pre- formed polymer, for example poly( d,l -lactide) -based nanocapsules containing an antitumoral agent [93] or poly(methyl methacrylate) ( PMMA ) capsules with an entrapped antiseptic agent [89] were successfully prepared (see Figure 17.6 f).…”

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

“…For example, by interfacial deposition of the preformed polymer, poly(D,L-lactide)-based nanocapsules containing an antitumoral agent 76 or poly (methyl methacrylate) capsules with an entrapped antiseptic agent 77 were successfully prepared. The modified nanoprecipitation of polymers onto stable nanodroplets with an antiseptic agent (see Table 1) has been successfully applied for the preparation of well-defined nanocapsules.…”