Preparation and characterization of selenium nanoparticles decorated by
            <i>Spirulina platensis</i>
            polysaccharide

Zhang, Xia; Yan, Haimeng; Ma, Lin; Zhang, Haoran; Ren, Difeng

doi:10.1111/jfbc.13363

Cited by 40 publications

(18 citation statements)

References 43 publications

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“…It is well known that natural seaweed polysaccharides have the potential to act as antioxidants in functional products (Zhang, Yan, Ma, Zhang, & Deng, 2020). In this study, the antioxidant ability of SFPS‐SeNPs was significantly stronger than that of bare SeNPs.…”

Section: Resultsmentioning

confidence: 99%

Preparation and antioxidant activity of selenium nanoparticles decorated by polysaccharides from Sargassum fusiforme

Zhao

Fan

2021

Journal of Food Science

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In this study, the response surface method was employed to optimize the extraction conditions of the ultrasonic‐assisted extraction of Sargassum fusiforme polysaccharides (SFPS). The effects of four independent variables (hot water extraction time, ultrasonic time, ultrasonic power, and material‐to‐liquid ratio) on the extraction rate of SFPS were tested. In addition, the SFPS functionalized nanoselenium (SFPS‐SeNPs) was prepared by chemical reduction method, whose characterization and in vitro antioxidant activity were investigated. The results showed that the yield of the crude SFPS was 25.8% at the optimal conditions of material‐to‐liquid ratio 1:50 (w/v), ultrasonic power 200 W, ultrasonic time 15 min, and water bath time 130 min. A series of characterization experiments showed that the SFPS‐SeNPs performed higher dispersion and stability than naked SeNPs. Furthermore, the in vitro antioxidant activity assay indicated that SFPS functioned as a modifier improved the free radical scavenging activity of SeNPs significantly. In conclusion, this study provided a method to extract SFPS as a carrier for SeNPs, and SFPS‐SeNPs could not only improve the stability of SeNPs, but also exerted the biological activities of SFPS. Practical Application This research provided new ideas for the application of SFPS and the development of nanoselenium preparation carriers.

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Section: Resultsmentioning

confidence: 99%

Preparation and antioxidant activity of selenium nanoparticles decorated by polysaccharides from Sargassum fusiforme

Zhao

Fan

2021

Journal of Food Science

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“…Since bare SeNPs produced by chemical synthesis are unstable in aqueous solutions ( Figure ‐b), leading to aggregates of stable gray/black Se, [ 15,106,117 ] stabilizers are usually added to preserve SeNPs size and bioactivity. [ 40,23 ] In fact, small changes in the SeNPs size may have an effect on their antioxidant activities, for example, by promoting Se accumulation and GSH S‐transferase activity in vivo.…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

254

146

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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“…For a colloidal solution, the stability is closely related to the size of the colloidal particle, that is, the smaller the particle size, the higher the stability. Therefore, the absorbance of Se-chestnut polysaccharides can be measured by the dual-wavelength method to assess a size change of nano-selenium particles (32)(33)(34)(35).…”

Section: Stability Determination Of Selenized Chestnut Polysaccharidementioning

confidence: 99%

Preparation of nano-selenium from chestnut polysaccharide and characterization of its antioxidant activity

Wang

Zhang

et al. 2023

Front. Nutr.

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Chestnut is widely cultivated and has high nutritional value due to its richness in polysaccharides. In order to improve the antioxidant activity of chestnut polysaccharide, chestnut polysaccharide (CP) was extracted by ultrasonic-assisted water extraction and alcohol precipitation and purified by cellulose DEAE-52 exchange and Sephadex G-100 chromatography in this study. CP isolates were characterized by I2-KI reaction, three-strand helical structure analysis, infrared spectrum analysis, and nuclear magnetic resonance detection. The results showed that CP is a pyrylan sugar with triple helical structure and connected by α-glycosidic bonds, with sugar residues 1,4-α-D-Glcp, 1,6-α-D-Galp, 1,5-α-L-Araf, 1,4-α-L-Rhap, and 1,4-β-D-Glcp in the CP backbone. After purification, the branching structure, rod, and spherical structure were significantly increased, with reduced lamellar structure. The in vitro scavenging rates of CP at 10 mg·mL−1 against DPPH, hydroxyl radicals, and ABTS were 88.95, 41.38, and 48.16%, respectively. The DPPH free radical scavenging rate of purified polysaccharide fraction CP-1a was slightly enhanced, and the other rates showed a small decrease. Selenized chestnut polysaccharide (CP-Se) was prepared using nano-selenium method. The selenization method was optimized and stable Se-CP was obtained. When the concentration was 5 mg·mL−1, Se-CP had significantly higher scavenging abilities 89.81 ± 2.33, 58.50 ± 1.60, and 40.66 ± 1.91% for DPPH, hydroxyl radical, and ABTS radicals, respectively, than those of CP. The results of this study provide insight into the effects purification and selenization of chestnut polysaccharide on antioxidant activity, and also provide a theoretical basis for the development of chestnut polysaccharide for use in functional foods or health products.

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Preparation and characterization of selenium nanoparticles decorated by Spirulina platensis polysaccharide

Cited by 40 publications

References 43 publications

Preparation and antioxidant activity of selenium nanoparticles decorated by polysaccharides from Sargassum fusiforme

Preparation and antioxidant activity of selenium nanoparticles decorated by polysaccharides from Sargassum fusiforme

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Preparation of nano-selenium from chestnut polysaccharide and characterization of its antioxidant activity

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