Preparation and characterization of shellac‐coated anthocyanin pectin beads as dietary colonic delivery system

Oehme, Anett; Valotis, Anagnostis; Krammer, Gerhard; Zimmermann, Ingfried; Schreier, Peter

doi:10.1002/mnfr.201000467

Cited by 41 publications

(27 citation statements)

References 54 publications

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“…Pectins can be crosslinked by PEC with positively charged dietary fiber (e.g., CS), ionic crosslinking with divalent cations (e.g., calcium or zinc), or covalent crosslinking with dialdehydes such as glutaraldehyde. For example, early work describing pectin-based encapsulation structure of anthocyanins for colonic delivery was based on ionically crosslinking pectin with calcium and an additional shellac coating layer (Oehme, Valotis, Krammer, Zimmermann, & Schreier, 2011;Oidtmann et al, 2012). Nonetheless, the loading capacity of anthocyanins in these systems is relatively low, which may be attributed to the less rigid matrix structure constructed by a calcium-induced ionotropic mechanism, or the high aqueous solubility of anthocyanins that are associated with low encapsulation in insoluble pectinate systems.…”

Section: Pectinmentioning

confidence: 99%

Dietary fiber-based colon-targeted delivery systems for polyphenols

Tang

Fang

2020

Trends in Food Science & Technology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Pectinmentioning

confidence: 99%

Dietary fiber-based colon-targeted delivery systems for polyphenols

Tang

Fang

2020

Trends in Food Science & Technology

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“…Excipients used for encapsulating various substances have included maltodextrin, β-cyclodextrin, pullulan, glucan gel, curdlan, sodium alginate and pectin [ 43 ]. In addition, others have used pectin and shellac to encapsulate anthocyanins [ 44 ]. In this study we decided to use only one natural building material for making microcapsules, which is soy lecithin.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

et al. 2018

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In our research we used the extract from dietary supplement of elderberry (EE) and its dominant anthocyanin—cyanidin 3-O-glucoside (Cy 3-gluc). By interacting with a model membrane that reflects the main lipid composition of tumor membranes, the extract components, including Cy 3-gluc, caused an increase in packing order, mainly in the hydrophilic region of the membrane. It can thus be stated that EE caused a rigidifying effect, which is fundamental for understanding its anticancer and antioxidant activity. This study represents the first attempt to unravel the mechanism of interaction of elderberry extract with membranes. The results of the interaction with human serum albumin (HSA) proved that the studied substance quenches the fluorescence of HSA through a static mechanism in which the main interaction forces are Van der Waals and hydrogen bonding. The antioxidant activity of EE and Cy 3-gluc on liposomal membranes, antiradical properties and ability to inhibited the activity of the enzymes cyclooxygenase-1 and cyclooxygenase-2 were also demonstrated. Moreover, the anticancer activity of EE and Cy 3-gluc on human breast adenocarcinoma cell line were investigated. In addition, EE also exhibited the ability to form lipid aggregates in the form of liposomal capsules that can be applied as carriers of active biological substances, and the highest efficacy of EE encapsulation was obtained for multilayered liposome formulations.

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“…Encapsulation promotes descended degradation from the external environment such as heat, light, moisture and oxygen during processing and storage. Further advantages are the prevention of interactions with other components, controlled release characteristics, the easier handling and masking of undesired sensory aspects as well as the increased bioavailability of the coated material [26][27][28][29].…”

Section: Lipid-based Delivery Systemsmentioning

confidence: 99%

Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

et al. 2020

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Phenolic compounds (quercetin, rutin, cyanidin, tangeretin, hesperetin, curcumin, resveratrol, etc.) are known to have health-promoting effects and they are accepted as one of the main proposed nutraceutical group. However, their application is limited owing to the problems related with their stability and water solubility as well as their low bioaccessibility and bioavailability. These limitations can be overcome by encapsulating phenolic compounds by physical, physicochemical and chemical encapsulation techniques. This review focuses on the effects of encapsulation, especially lipid-based techniques (emulsion/nanoemulsion, solid lipid nanoparticles, liposomes/nanoliposomes, etc.), on the digestibility characteristics of phenolic compounds in terms of bioaccessibility and bioavailability.

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Preparation and characterization of shellac‐coated anthocyanin pectin beads as dietary colonic delivery system

Abstract: In the used in vitro and ex vivo model system mimicking the human intestinal transit, the potential of shellac and shellac/HPMC coated anthocyanin amidated pectin beads as dietary colon targeting systems was demonstrated.

Cited by 41 publications

References 54 publications

Dietary fiber-based colon-targeted delivery systems for polyphenols

Dietary fiber-based colon-targeted delivery systems for polyphenols

A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

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