Preparation and Characterization of Some New Schiff Bases Compounds with the Study of Biological Effectiveness

Abstract

A new series of Schiff bases compounds that contains a set of one or more azomethine groups through the reactance compounds (3-Morpholino-1-(3-nitrophenyl)-3-(4nitrophenyl) propan-1-one, Terephthalaldehyde, Benzylidene acetophenone) with different aromatic amines (2-Aminobenzothiazole, 4-Bromo-2-methylaniline, 5-(4methoxyphenyl)-1,3,4-thiadiazol-2-amine, 4-amino-N-(5-methyl isoxazol-3-yl) benzenesulfonamide, 2-Aminoanthracene-9,10-dione, 4-(phenyldiazenyl) aniline, 5-(2chlorophenyl)-1,3,4-thiadiazol-2-amine, Melamine, P-Phenylenediamine) using glacial acetic acid as a catalyst agent (1-10). The synthesized compounds were identified using physical and spectral methods (melting points, colour change, Thin Layer Chromatography, infrared spectra, ultraviolet spectra and nuclear magnetic resonance spectra) and biological effectiveness has also been measured for some of the prepared compounds against the growth of bacteria, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Compounds [1, 4, 7, 8 and 10] showed moderate antibacterial activity (inhibition zone 11-20 mm) on Staphylococcus aureus.

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“…The specific bands of IR spectra of prepared compounds are summered in spectra of complexes appear bands around 3276-3486cm -1 assigned to (OH) molecules of H2O related to the complexes [18]. From 1627-1659 cm -1 , complexes' (C=N) band is shifted towards lower wavenumbers than the free ligand band at 1676cm -1 [9]. This change shows that the two groups of (C=N) have coordinated with the metal ions.…”

“…Microwave methods have been commonly utilized to prepare Schiff base by synthesizing organic [8]. Furthermore, they have a wide range of applications in biological [9], clinical [10], medicinal [11], electrochemistry [12], analytical [13], and industrial [14] research, as well as being used as medicinal [15], liquid crystals [16] in analytical, and polymer chemistry [17].Chemists of organic are attentive to prepare Schiff bases attributed to such considerable activities of biological [18]. Cancer [19], metalmediated antibiotics [20], antiviral [21], radio sensitizers [22], antibacterial [23], and antiparasitic research are all underway [24].…”