A new series of Schiff bases compounds that contains a set of one or more azomethine groups through the reactance compounds (3-Morpholino-1-(3-nitrophenyl)-3-(4nitrophenyl) propan-1-one, Terephthalaldehyde, Benzylidene acetophenone) with different aromatic amines (2-Aminobenzothiazole, 4-Bromo-2-methylaniline, 5-(4methoxyphenyl)-1,3,4-thiadiazol-2-amine, 4-amino-N-(5-methyl isoxazol-3-yl) benzenesulfonamide, 2-Aminoanthracene-9,10-dione, 4-(phenyldiazenyl) aniline, 5-(2chlorophenyl)-1,3,4-thiadiazol-2-amine, Melamine, P-Phenylenediamine) using glacial acetic acid as a catalyst agent (1-10). The synthesized compounds were identified using physical and spectral methods (melting points, colour change, Thin Layer Chromatography, infrared spectra, ultraviolet spectra and nuclear magnetic resonance spectra) and biological effectiveness has also been measured for some of the prepared compounds against the growth of bacteria, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Compounds [1, 4, 7, 8 and 10] showed moderate antibacterial activity (inhibition zone 11-20 mm) on Staphylococcus aureus.

In this paper the compounds (11-20) (methyl pyrimidine-2(1H)-one and others phenyl pyrimidine-2(1H)-one) that had been already prepared from α, β unsaturated carbonyl compounds that are called chalcones, these compounds are usually prepared from the reaction of different aldehydes (4-methoxy benzaldehyde, 2-nitro benzaldehyde, 3-nitrobenzaldehyde, 4-N,N-dimethyle amino benzaldehyde, benzaldehyde, 4-nitrobenzaldehyde) with different ketones (acetone, acetophenone, 2-nitro acetophenone, 3nitro acetophenone) After preparing and purifying them a suitable mesurment for physical, chemical and spectroscopic properties had been made to get chalcones that reacted with urea under known chemical conditions to get the pyrimidinone compounds that we need. Pyrimidine compounds had been reacted with two aromatic amines (2,4dinitro aniline and 4-amino acetophenone) using glacial acetic acid as catalyst in absolute ethanol giving a new compounds of schiff's bases (21-40). New thiazolidine 4-one (41-50) had been synthesized from the reacting of Schiff's bases (21-30) with thioglycolic acid in absolute ethanol. 1,3-oxazepine derivatives. (51-60) had been prepared from reaction between Schiff's bases (31-40) and malic anhydrid in absolut ethanol. The structures of the Synthesized compounds had been estimated by IR, 1 H-NMR and some physical data.

This study involved synthesize (1,3) oxazepine. The step 1 includes the preparation of compound (1), (5-Bromo-2-mercapto-6-(4-methoxyphenyl) pyrimidin-4(3H)-one), by the condensation of anisaldehyde and ethylbromoacetat and thiourea in EtOH. In the step2, chalcones (2-6) have been produced. The reaction of compound (1) with chalcones (2-6) that gives azo Michael adduct (7-11) is made in the third step. Schiff's bases (12-16) were prepared by the reaction ketones (7-11) with 2,4dinitroaniline. Finally preparation of new benzo [1,3] oxazepine compounds (17-21) are prepared by the reaction of phthalic anhydride with Schiff's bases. The synthesized compounds are identified by physical (melting points, colour change) and spectral methods such as (IR, proton-nmr).

Comparative Studies of the Deprotection of Various Acid-Sensitive Protecting Groups with Pyridinium p-Toluenesulphonate.-Py·TosOH is elaborated as reagent for selective deprotection of various acidsensitive protecting groups such as ethoxyethyl, tert butyldimethylsilyl and tert butoxycarbonyl under mild conditions. - (ZAIDI, J. H.; FAUQ, A. H.; AHMED, N.; Tetrahedron Lett. 39 (1998) 23, 4137-4138; Dep. Chem., Fed. Cov. Coll., Islamabad 45320, Pak.; EN)

As shown for (IVa) and (IVb), a variety of title compounds such as (IV) or (V) are prepared.