Synthesis of Some New Benzoxazepine Compounds Form Derivatives of Schiff Bases

Abstract

This study involved synthesize (1,3) oxazepine. The step 1 includes the preparation of compound (1), (5-Bromo-2-mercapto-6-(4-methoxyphenyl) pyrimidin-4(3H)-one), by the condensation of anisaldehyde and ethylbromoacetat and thiourea in EtOH. In the step2, chalcones (2-6) have been produced. The reaction of compound (1) with chalcones (2-6) that gives azo Michael adduct (7-11) is made in the third step. Schiff's bases (12-16) were prepared by the reaction ketones (7-11) with 2,4dinitroaniline. Finally preparation of new benzo [1,3] oxazepine compounds (17-21) are prepared by the reaction of phthalic anhydride with Schiff's bases. The synthesized compounds are identified by physical (melting points, colour change) and spectral methods such as (IR, proton-nmr).

Synthesis, Characterization of New Phenylene Bis Tetrazole and Bis Benzoxazepinedione Derivatives from some Bis Imines with its Biological Activity Assessment.

“…Imine compounds can be converted to cyclic product by treating it with maleic anhydride resulting in oxazepinediones [5]. Additionally, imines transferred to Benzoxazepinediones when phthalic anhydride reacted with it [6], [7]. Another cycliza-tion reaction is the dealing imines with mercaptobenzoic acid or aminobenzoic acid to form benzothiazinones and quinazolinones respectively [8], [9].…”