Preparation and characterization of stearic acid-pullulan nanoparticles

Kim, Insook; Oh, In-Joon

doi:10.1007/s12272-010-0516-7

Cited by 10 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pullulan, which is a water-soluble, neutral, linear polysaccharide, has properties of biocompatibility and biodegradability. These attributes have been exploited in the extensive biomedical use of pullulan as a nanomaterial [17,[20][21][22]. Since pullulan is highly water-soluble, copolymerization with PLGA endowed amphiphilic properties to copolymers, i.e., pullulan backbone acts as a hydrophilic domain and PLGA acts as a hydrophobic domain [17].…”

Section: Discussionmentioning

confidence: 99%

Folic-acid-conjugated pullulan/poly(DL-lactide-co-glycolide) graft copolymer nanoparticles for folate-receptor-mediated drug delivery

Lee¹,

Shim²,

Oh³

et al. 2016

Nano Online

View full text Add to dashboard Cite

Background: Nanoparticles have been extensively investigated for targeted delivery of anticancer drugs. Since the folate receptor is universally over-expressed on the tumor cell membrane, folic acid is often used to modify the fate of nanoparticles in biologicals. Methods: To fabricate targetable nanoparticles, folic acid was conjugated to a pullulan backbone and poly(DL-lactide-co-glycolide) (PLGA) (abbreviated as FAPuLG) was conjugated. KB cells and NIH3T3-cell-bearing mice were prepared to prove folate receptor targeting of FAPuLG nanoparticles. Results and discussion: Nanoparticles of FAPuLG copolymer that self-assembled in water were small with diameters <200 nm. Doxorubicin (DOX) as a model drug was incorporated into the FAPuLG nanoparticles that were used to treat folate receptor over-expressing KB human carcinoma cells. Fluorescence microscopy revealed that DOX-incorporated FAPuLG nanoparticles induced strong red fluorescence in the KB cells in the absence of folic acid. However, fluorescence intensity was decreased by blocking folate receptors. Antitumor activity of FAPuLG nanoparticles against KB cells in vitro was also decreased by blocking folate receptors. In animal study using near-infrared dye-conjugated FAPuLG nanoparticles, fluorescence intensity was significantly higher at KB solid tumor than that of NIH3T3. Conclusions: The results indicate that FAPuLG nanoparticles can target the folate receptor of tumor cells. FAPuLG nanoparticles are a promising candidate for active targeting of anticancer agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Folic-acid-conjugated pullulan/poly(DL-lactide-co-glycolide) graft copolymer nanoparticles for folate-receptor-mediated drug delivery

Lee¹,

Shim²,

Oh³

et al. 2016

Nano Online

View full text Add to dashboard Cite

show abstract

“…Therefore, the degree of crystallinity of biotin was high. 47,48 There were many crystal diffraction peaks in the biotin spectrum, then POP had only one diffraction peak, which was a broad and diffuse diffraction peak at 2q of 19.81 . Relative to POP, the spectrum diffraction peak of Bio-POP conjugates was slightly shied at 2q of 18.95 .…”

Section: Xrd Analysismentioning

confidence: 99%

Synthesis and biological evaluation of biotin-conjugated Portulaca oleracea polysaccharides

et al. 2021

View full text Add to dashboard Cite

show abstract

“…to produce nanoparticulate assemblies. [150][151][152] These nanoassembled materials have been widely exploited for physical loading of other drugs like NSAIDs and anti-cancer agents [153][154][155] using solvent displacement, nanoprecipitation, dialysis and desolvation methods.…”

Section: Polysaccharide-drug Conjugate Nanoassemblies As Potential Ca...mentioning

confidence: 99%

Polysaccharide-based materials in macromolecular prodrug design and development

Hussain

Abbas

Jantan

et al. 2016

International Materials Reviews

View full text Add to dashboard Cite

This review summarises the recent efforts to engineer macromolecular prodrugs (MPDs) based on polysaccharidal materials. Polysaccharidal materials are of utmost importance to design and develop MPDs of non-steroidal anti-inflammatory drugs, antibiotics, anti-viral and anti-cancer drugs, etc. Covalent drug loading capabilities of the polysaccharidal materials are thoroughly discussed. In order to successfully transform drugs into prodrugs using polysaccharidal materials, present review details different syntheses strategies which are being applied to design pharmaceutically viable MPDs. Herein, we also reported the collection of polysaccharidal materials which are being widely spun in to MPDs of several classes of drugs and their applications. Merits and demerits of polysaccharide biomaterials for MPDs are critically discussed. Cellulose ether derivatives are newly introduced materials attracting the vigil eye of researchers working in MPD design for potential therapeutic applications. Special emphasis will be given to amphiphilic materials, i.e. MPDs, which self-assemble at solvent interfaces into nanorods, nanoparticles (NPs), nanowires, etc. Furthermore, the stability of MPDs at elevated conditions of temperature is discussed to gain information about their storage properties. We highlighted thrust areas in polysaccharidal materials-based research and development of MPDs.

show abstract

Preparation and characterization of stearic acid-pullulan nanoparticles

Cited by 10 publications

References 22 publications

Folic-acid-conjugated pullulan/poly(DL-lactide-co-glycolide) graft copolymer nanoparticles for folate-receptor-mediated drug delivery

Folic-acid-conjugated pullulan/poly(DL-lactide-co-glycolide) graft copolymer nanoparticles for folate-receptor-mediated drug delivery

Synthesis and biological evaluation of biotin-conjugated Portulaca oleracea polysaccharides

Polysaccharide-based materials in macromolecular prodrug design and development

Contact Info

Product

Resources

About