Preparation and characterization of succinyl chitosan and succinyl chitosan nanoparticle film: In vitro and in vivo evaluation of wound healing activity

Thảo, Nguyễn Tiến; Wijerathna, H.M.S.M.; Kumar, Rajesh; Choi, Dong-Rack; Dananjaya, S.H.S.; Attanayake, Anoja Priyadarshani

doi:10.1016/j.ijbiomac.2021.11.015

Cited by 29 publications

(7 citation statements)

References 59 publications

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“…Chitosan possesses various highly desirable features, which include biocompatibility and versatility as far as formulation techniques are concerned. These characteristics make chitosan a highly sought after biomaterial with technological applications in cosmetics [ 40 , 41 ], pharmaceutical [ 42 , 43 ], and biomedical [ 44 , 45 ] industries. However, despite all this, as this review will highlight, there is a deficiency of usage of chitosan in the formulation of nanoparticulate technologies that can be used for, and are being used for, atherosclerosis research (diagnostics, therapeutics, and theranostics).…”

Section: Chitosan—a Promising Biopolymer That Has Potential In Athero...mentioning

confidence: 99%

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Sriamornsak

Dass

2022

Pharmaceutics

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Chitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance of papers has tested this biopolymer in nanoparticles in cancer and diabetes research, there is a lag of usage, and hence the paucity of information, in the area of cardiovascular research, specifically in atherosclerosis, the topic of this review. This review highlights some of the deficiencies in this niche area of research, examines the range of chitosan nanoparticles that have been researched to date, and proposes several ways forward to advance this field. Nanoparticles used for both diagnostic and therapeutic purposes are reviewed, with a discussion on how these nanoparticles could be better researched in future and what lays ahead as the field potentially moves towards clinical trials in future.

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Section: Chitosan—a Promising Biopolymer That Has Potential In Athero...mentioning

confidence: 99%

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Sriamornsak

Dass

2022

Pharmaceutics

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“…However, it was observed that, unlike the free molecules, there was a low hemolytic activity observed for peptide conjugation. This would indicate that a formulation using MIC values would be sufficient for dermatological application in order to avoid hemolysis and prevent the entry of pathogens into open wounds . Likewise, this formulation can be a promising protective film for foods since other films previously reported in the literature presented values above those reported in this study. − …”

Section: Resultsmentioning

confidence: 99%

Conjugation of Ctx(Ile²¹)-Ha Antimicrobial Peptides to Chitosan Ultrathin Films by N-Acetylcysteine Improves Peptide Physicochemical Properties and Enhances Biological Activity

et al. 2022

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The importance of obtaining new compounds with improved antimicrobial activity is a current trend and challenge. Some polymers such as chitosan have shown promising bactericidal properties when they are structurally modified, which is due to the binding versatility provided by their free amines. Likewise, antimicrobial peptides (AMPs) have received attention in recent years because of their bactericidal activity that is similar to or even better than that of conventional drugs, and they exhibit a low induction rate of antimicrobial resistance. Herein, the modified AMP Ctx(Ile 21 )-Ha-Ahx-Cys was conjugated to chitosan using N -acetylcysteine as an intermediate by the carbodiimide method. Films were prepared using protonated chitosan in 1% acetic acid and Ctx(Ile 21 )-Ha-Ahx-Cys AMP dissolved in N -acetylcysteine-chitosan; 1.6 mmol of ethylcarbodiimide hydrochloride, 1.2 mmol of N -hydroxysulfosucchimide, and 0.1 mol L –1 of N -morpholino)ethanesulfonic acid buffer at pH 6.5 by continuous stirring at 100 × g for 10 min at 37 °C. Physicochemical properties were evaluated by Fourier-transform infrared spectroscopy, differential scanning calorimetry/thermogravimetric analysis, and X-ray diffraction to determine the mechanical properties, solubility, morphology, and thickness. Furthermore, the antimicrobial activities of chitosan-based conjugated films were evaluated against Staphylococcus aureus , Pseudomonas aeruginosa , Salmonella Typhimurium, and Escherichia coli . The results showed that the conjugation of a potent AMP could further increase its antibacterial activity and maintain its stable physicochemical properties. Therefore, the developed peptide–chitosan conjugate could be applied as an additive in surgical procedures to prevent and combat bacterial infection.

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“…This issue is also highlighted in Figure 7a-c The next part of this curl drop test studied the effects of chitosan on the longevity of the curls. Chitosan exhibits an excellent ability to form a film around the hair tresses, acting as a protectant between the hair itself and damaging heat [37,38]. As seen in Figure 7a-c, there is quite a bit of separation between the strands of hair as the chitosan concentration increases, especially in Samples 9 and 10.…”

Section: Curl Drop Testmentioning

confidence: 97%

Methylcellulose-Chitosan Smart Gels for Hairstyling

2022

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Methylcellulose and chitosan served as promising ingredients for a thermoresponsive hair styling gel after successful application in the medical industry. Both ingredients uphold the clean beauty standard without infringing on performance. By combining these two ingredients, a hair gel can be created that promises an extended hold of style once a heated external stimulus, such as a curling wand, is applied to the hair. Chitosan serves as the cationic biopolymer to adhere the gel to the hair, whereas the methylcellulose acts as the smart biopolymer to lock the desired hairstyle in place. Various ranges of chitosan and methylcellulose concentrations were explored for formulation optimization with rheology and curl drop testing. The rheology testing included a flow sweep test to understand the shear-thinning behavior of the sample as well as the effect of concentration on viscosity. Another rheology test completed was a temperature ramp test from room temperature (25 °C) to 60 °C to study the effect of heat on the various concentrations within the samples. A curl drop test was performed as well, over a 48-h period in which the different samples were applied to wet hair tresses, dried, curled, and hung vertically to see how the style held up over a long period of time with the influence of gravity.

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Preparation and characterization of succinyl chitosan and succinyl chitosan nanoparticle film: In vitro and in vivo evaluation of wound healing activity

Cited by 29 publications

References 59 publications

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Conjugation of Ctx(Ile²¹)-Ha Antimicrobial Peptides to Chitosan Ultrathin Films by N-Acetylcysteine Improves Peptide Physicochemical Properties and Enhances Biological Activity

Methylcellulose-Chitosan Smart Gels for Hairstyling

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Preparation and characterization of succinyl chitosan and succinyl chitosan nanoparticle film: In vitro and in vivo evaluation of wound healing activity

Cited by 29 publications

References 59 publications

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Conjugation of Ctx(Ile21)-Ha Antimicrobial Peptides to Chitosan Ultrathin Films by N-Acetylcysteine Improves Peptide Physicochemical Properties and Enhances Biological Activity

Methylcellulose-Chitosan Smart Gels for Hairstyling

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Product

Resources

About

Conjugation of Ctx(Ile²¹)-Ha Antimicrobial Peptides to Chitosan Ultrathin Films by N-Acetylcysteine Improves Peptide Physicochemical Properties and Enhances Biological Activity