Preparation and characterization of sulfated inulin-type fructans from Jerusalem artichoke tubers and their antitumor activity

Shao, Taili; Yuan, Ping; Zhang, Wenzhi; Dou, De-Yu; Wang, Fengge; Hao, Chengyi; Liu, Chunyan; Han, Jun Hyun; Chen, Kaoshan; Wang, Guodong

doi:10.1016/j.carres.2021.108422

Cited by 16 publications

(9 citation statements)

References 39 publications

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“…The simultaneous presence of →1)-β- d -Fru f -(2→ and →1,6)-β- d -Fru f -(2→ linkages demonstrated that the structure of PCP1 might have side chains. 9 The linkage order of the residues was determined from the HMBC spectrum (Fig. 3F), and the cross-signal at δ 3.63/104.08 ppm (A H1/B C2) indicated that H1 of residue A was linked to C2 of residue B.…”

Section: Resultsmentioning

confidence: 99%

“…The 1 H nuclear magnetic resonance (NMR), 13 C NMR, 1 H-1 H correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlation (HMBC) spectra were recorded at 25 °C using a JNM-ECZ600R/S1 spectrometer (600 MHz, JEOL, Japan). 9 The data were analyzed using the MestReNova (6.1.0-6224) software.…”

Section: Papermentioning

confidence: 99%

“…5,6 Furthermore, they exhibit various bio-active properties in the form of hypolipidemic, hypoglycemic, antioxidative, antitumor, and anti-inflammatory properties, which have increased their medicinal value. [7][8][9] Oxidative stress is an important mechanism in the pathogenesis of NAFLD, and an imbalance in the intestinal flora composition can promote its occurrence and development. 10 Polysaccharides can reduce oxidative stress damage, repair bacterial population imbalance, and improve intestinal permeability by regulating the abundance of beneficial or specific bacteria and promoting the production of short-chain fatty acids (SCFAs).…”

Section: Introductionmentioning

confidence: 99%

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Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

et al. 2022

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“…The FT-IR spectra of the modified polysaccharides show new characteristic peaks after introducing new groups. A sulfated polysaccharide shows a characteristic peak near 1250 cm −1 , caused by S=O.Another characteristic peak will appear near 810 cm −1 due to C-O-S symmetry vibration [ 48 , 54 ]. After the polysaccharide is attached to the phosphate group, characteristic peaks appear near 1033 and 898 cm −1 , attributed to the P-OH and P-O-C bonds, respectively.…”

Section: Characterization Of Polysaccharidesmentioning

confidence: 99%

Chemical Modification, Characterization, and Activity Changes of Land Plant Polysaccharides: A Review

Wang

et al. 2022

Polymers

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Plant polysaccharides are widely found in nature and have a variety of biological activities, including immunomodulatory, antioxidative, and antitumoral. Due to their low toxicity and easy absorption, they are widely used in the health food and pharmaceutical industries. However, low activity hinders the wide application. Chemical modification is an important method to improve plant polysaccharides’ physical and chemical properties. Through chemical modification, the antioxidant and immunomodulatory abilities of polysaccharides were significantly improved. Some polysaccharides with poor water solubility also significantly improved their water solubility after modification. Chemical modification of plant polysaccharides has become an important research direction. Research on the modification of plant polysaccharides is currently increasing, but a review of the various modification studies is absent. This paper reviews the research progress of chemical modification (sulfation, phosphorylation, acetylation, selenization, and carboxymethylation modification) of land plant polysaccharides (excluding marine plant polysaccharides and fungi plant polysaccharides) during the period of January 2012–June 2022, including the preparation, characterization, and biological activity of modified polysaccharides. This study will provide a basis for the deep application of land plant polysaccharides in food, nutraceuticals, and pharmaceuticals.

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“…Экстрагированный из клубней топинамбура инулин проявляет эффективную противо-опухолевую активность и применяется в качестве средств доставки лекарств, иммуностимуляторов и адъюванта вакцины [13, 14,15,16,17].…”

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System analysis of the state and prospects for the development of the production of inulin (review)

Бызов¹

2022

Аграрная наука Евро-Северо-Востока

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The review informs on the results of the research of the application of inulin as a bioactive prebiotic in functional nutritional products, in cosmetic formulations and pharmaceuticals as the excipient of anticancer agents on the basis of the system analysis. The steady trend of the world growth of inulin production of 8-10 % a year has been noted. The aim of the research is to reveal and to analyze the effect of the system complex of inulin production in sequential chain from the inulin synthesis, its accumulation in plants and extraction. The Jerusalem artichoke is the most advanced kind of raw material which has the high crop yield of tubers up to 40 t/ha and inulin content up to 20 %. The sucrose and the synthesizing enzymes 1-SST and 1-FFT take an active part in the inulin biosynthesis as their genes can be edited with the purpose of changing the inulin content. At the Jerusalem artichoke breeding the most prospective trend is the cross-species hybridization drawing on the example of a topinsunflower with the crop yield of tubers of 40 t/ha. In the Jerusalem artichoke seed breeding the new methods of clonal micropropagation of tubers and its cultivation in the airhydroponic environment with the achievement of the inulin content no less than 20 % have been studied. At Jerusalem artichoke cultivation the breed is significative for the maximum crop yield of tubers with the row width of 90 cm and with the interval between tubers in a row – 30 cm. The least loss of the tubers weight and the inulin content in them under the long-term storage is achieved at the temperatures from -5 to 0 °C. The technology of the Jerusalem artichoke tubers processing into inulin is suggested as the system of partly optimized technological operations from peeling and washing the tubers to receiving the powdered inulin and the oligofructose syrup. The system complex is suggested in the form of the structural topological model combining 4 systems: «Selection and seed breeding», «Agritechnologies», «Harvesting and storage of tubers», «The tubers processing technologies» with the interrelations in the form of the technological requirements and the output data of every system and of the complex as a whole, which is the basis for the development of the agri-food technology of inulin from Jerusalem artichoke and other kinds of raw materials.

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Preparation and characterization of sulfated inulin-type fructans from Jerusalem artichoke tubers and their antitumor activity

Cited by 16 publications

References 39 publications

Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

Chemical Modification, Characterization, and Activity Changes of Land Plant Polysaccharides: A Review

System analysis of the state and prospects for the development of the production of inulin (review)

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