Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate

Ma, Huili; Qi, Xian; Maitani, Yoshie; Nagai, Tsuneji

doi:10.1016/j.ijpharm.2006.10.006

Cited by 219 publications

(121 citation statements)

References 37 publications

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“…Various strategies for coating MIONPs in order to prevent agglomeration and to increase blood circulation time have been developed using natural and synthetic polymers such as alginate, 42 dextran, 48 liposome, 39 polyvinylpyrrolidone, 12 and PEG. 41,43 Some of the limitations involved in the existing approaches are lack of stabilization in body fluid, difficulty reaching targeted cell types, and difficulty retaining sufficient magnetic property.…”

Section: Discussionmentioning

confidence: 99%

“…MIONPs exhibited two peaks at 571 cm −1 and 590 cm −1 because of the iron oxide cores. [41][42][43] The peaks at 919, 1215, 1328, 1388, 1505, 1617, and 2931 cm −1 were assigned to C-H out-of-plane bending, aliphatic C-N stretching, aliphatic C-O stretching, Si-CH 2 scissoring, C-H bending, NH 2 scissoring and N-H bending, and CH 2 stretching, respectively. 41,44,45 After eosin binding, new bands that appeared at 1456 cm −1 and 1541 cm −1 corresponded to aromatic C=C stretching of eosin.…”

Section: Synthesis and Characterization Of Mionpsmentioning

confidence: 99%

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RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells

Nazli¹,

Ergenc²,

Yar³

et al. 2012

IJN

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Abstract:The objective of this study was to develop thin, biocompatible, and biofunctional hydrogel-coated small-sized nanoparticles that exhibit favorable stability, viability, and specific cellular uptake. This article reports the coating of magnetic iron oxide nanoparticles (MIONPs) with covalently cross-linked biofunctional polyethylene glycol (PEG) hydrogel. Silanized MIONPs were derivatized with eosin Y, and the covalently cross-linked biofunctional PEG hydrogel coating was achieved via surface-initiated photopolymerization of PEG diacrylate in aqueous solution. The thickness of the PEG hydrogel coating, between 23 and 126 nm, was tuned with laser exposure time. PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles. RGDS-bound PEG hydrogel-coated MIONPs showed a 17-fold higher uptake by the human cervical cancer HeLa cell line than that of amine-coated MIONPs. This novel method allows for the coating of MIONPs with nano-thin biofunctional hydrogel layers that may prevent undesirable cell and protein adhesion and may allow for cellular uptake in target tissues in a specific manner. These findings indicate that the further biofunctional PEG hydrogel coating of MIONPs is a promising platform for enhanced specific cell targeting in biomedical imaging and cancer therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Synthesis and Characterization Of Mionpsmentioning

confidence: 99%

RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells

Nazli¹,

Ergenc²,

Yar³

et al. 2012

IJN

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“…X-ray diffraction patterns of T30 and H1, H2 exhibited the typical crystal structure of spinel ferrite at diffraction peaks at 30.4° (220) , 35.5° (311), 43.5° (400), 57.1° (511), 62.9° (440) [6] indicating the successful formation of iron oxide magnetic particles. However, the presence of alginate caused the peaks of (200), (400), (511), (440) Since the (311) peak is the most prominent peak for all samples, the average grain sizes of Fe 3 O 4 nanoparticles were calculated based on the Scherrer equation for the (311) peaks.…”

Section: Crystal Structure Of Materials Characterized By Xrd and Tem mentioning

confidence: 99%

“…FT-IR spectrum of iron oxide (T30) exhibits characteristic vibrations in low frequency region (1000-500 cm -1 ) [6]. Two absorption bands appear at 580, 450 cm -1 attributed to the stretching vibration mode of Fe-O bonds in the tetrahedral and octahedral sites in Fe 3 O 4 , respectively.…”

Section: Characterizationsmentioning

confidence: 99%

“…The incorporations of magnetic nanoparticles in alginate for biomedical application were reported [5]. Generally, MNP was synthesized by coprecipitation and then loaded into alginate hydrogel [6,7] or by in-situ coprecipitation of Fe(II) and Fe (III) in the sodium-or calcium-alginate matrix [5,8]. Briefly, the particle sizes in the previous reports were varied from 5 to over 100 nm.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Magnetic Hydrogel by in-Situ Coprecipitation Process

Nguyen¹

2018

JST

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This study describes a preparation of magnetite nanoparticle by co-precipitation of Fe(II) and Fe(III) in alginate hydrogel matrix. This simple process is sufficient for producing a superparamagnetic, well dispersible magnetite nanoparticle in polymer hydrogel matrix. Two approaches for iron ions loadings are induced. The first approach includes two steps, the hydrogel beads are formed before the iron ions are being diffused into the hydrogel matrix. The second approach is the simultaneous forming of hydrogel containing iron ions. The ions loaded hydrogel is then coprecipitated in the presence of ammonium hydroxide to afford iron oxide magnetite nanoparticles in alginate hydrogel matrix. The composition and characteristics of the hydrogel containing magnetite nanoparticle were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). The results showed that the particles size of magnetic nanoparticles prepared by in-situ coprecipitation method is around ~ 6 nm and smaller than that produced by normal coprecipitation method. The magnetic hydrogel exhibits superparamagnetic properties with the saturation magnetization of about 25 emu/g, the ratio of Mr/Ms about 0.8 ×10 -3 . Possessing the biocompatibility as well as superparamagnetism, the magnetite hydrogel is a promising materials for environmental and biomedical applications.

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Magnetic Bionanocomposites

Luo

et al. 2017

Bionanocomposites

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Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate

Cited by 219 publications

References 37 publications

RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells

RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells

Preparation of Magnetic Hydrogel by in-Situ Coprecipitation Process

Magnetic Bionanocomposites

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