Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Zheng, Zuncheng; Wang, Xiaoyu; Du, Xiaojing

doi:10.4314/tjpr.v14i10.3

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…Hardness was tested by using Monsanto hardness tester (US). Twenty tablets of each batch were evaluated for weight variation (WV) [16]. Individual and average weights were calculated.…”

Section: Physicochemical Evaluationsmentioning

confidence: 99%

Preparation and pre-clinical characterization of sustainedrelease ketoprofen implants for the management of pain and inflammation in osteoarthritis

Zhang¹,

Xu²,

Lin³

et al. 2018

Trop. J. Pharm Res

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“…Hardness was tested by using Monsanto hardness tester (US). Twenty tablets of each batch were evaluated for weight variation (WV) [16]. Individual and average weights were calculated.…”

Section: Physicochemical Evaluationsmentioning

confidence: 99%

Preparation and pre-clinical characterization of sustainedrelease ketoprofen implants for the management of pain and inflammation in osteoarthritis

Zhang¹,

Xu²,

Lin³

et al. 2018

Trop. J. Pharm Res

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“…Absorbance of the solution was analysed spectrophotometrically at 238 nm against suitable blank using UV-visible Spectrophotometer (1800, Shimadzu, Kyoto, Japan) and drug content per tablet was calculated. 16 In vitro drug release studies: In vitro dissolution of Simvastatin sustained release formulation were studied in USP type-2 dissolution apparatus employing a paddle stirrer at 50 rpm using 900 ml of phosphate buffer solution at pH 1.2, 6.8 as dissolution medium maintain at temperature of 37±0.5 0 C. One tablet was used in each test. Aliquots of dissolution medium (1 ml) were withdrawn at the regular intervals of time (1 hour) and equivalent amount of fresh medium was replaced to maintain a constant volume.…”

Section: Thicknessmentioning

confidence: 99%

Design and Evaluation of Sustained Release Matrix Tablets of Antihyperlipidemic Drug

Chaudhari¹,

Vyawahare²,

Phad³

2018

AJPTR

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The aim of present work was to design and evaluate sustained release matrix tablets of antihyperlipidemic drug. In the present investigation, polymers used in different combinations such as Eudragit RL100 and HPMC E5 in the ratio of 1:1, 1:2, 1:3 and vice versa with PVP K25 using direct compression technique were prepared. The tablets were evaluated for physical parameters like thickness, hardness, friability, weight variation, and in vitro release studies. The FTIR study indicated that the drug is stable in formulation. The maximum drug release was found to be 94.41% over a period for 12 hours for F4 batch, thus concluded that as the concentration of Eudragit RL100 is increased the drug release decreased. The drug release mechanism followed non-fickian transport from both polymer matrices. All the formulations were stored at 25 0 C/60% RH and 45 0 C/75% RH for 3 months. It showed that all the formulations were physically and chemically stable.

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“…s NOTE: x ranges from 0-20 % Each batch of 20 g of granule was prepared by incorporating either Raphia gum extract or PVP as a binder at 5%, 10%, 15% and 20% with other ingredients as presented in table (1). Appropriate quantities of diclofenac sodium, cornstarch and lactose were weighed out and mixed using mortar and pestle to obtain a homogenous mix.…”

Section: Preparation Of Diclofenac Granulesmentioning

confidence: 99%

“…The sustained release pharmaceutical delivery system is formulated to retard the release of a therapeutic agent such that its appearance in the systemic circulation is delayed and/or prolonged and its plasma profile is sustained in duration [1]. This duration is in hours for oral dosage forms and varies from days to months in the case of parenteral products.…”

Section: Introductionmentioning

confidence: 99%

Optimized Delivery of Diclofenac Sodium Formulated in a Sustained Release Raphia Africana Hydrocolloid Matrix

Adedokun

Nkanta

2018

Int J App Pharm

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Objective: The aim of this research work was to comparatively study various proportions of a natural hydrocolloid-Raphia africana, and polyvinylpyrrolidone (PVP) as release sustaining agents in diclofenac sodium tablet formulation. Methods:The purified hydrocolloid (R. africana) was characterized by evaluating its organoleptic, physicochemical and flow properties. Diclofenacpolymer ratios of 1:0, 1:0.2, 1:0.4, 1:0.6, and 1:0.8 were employed to produce different granule batches using wet granulation method (that is, the drug was formulated with 0, 5, 10, 15 and 20 % w/w of either R. africana hydrocolloid or PVP, and coded DWB-00, DRA-05, DRA-10, DRA-15, DRA-20, DPP-05, DPP-10, DPP-15 and DPP-20, respectively). Flow properties of granules were studied by determining bulk density, tapped density, Carr's index, and Hausner's ratio for all the formulations. Compressed tablets were evaluated using various parameters as weight variation, friability, hardness, tablet thickness and diameter, content uniformity and in vitro dissolution evaluated in phosphate buffer (pH 7.3).Results: Flowability, mechanical and release parameters determined were within pharmacopoeial limits. Generally, the values of bulk and tapped densities increase as binder concentrations increase for both PVP and R. africana hydrocolloid. The values were significantly different across the batches (p<0.05). Hardness values obtained varied significantly (p<0.05) and were between 5 and 12 KgF which imply that most of the tablet batches are harder than normal depending on the proportion of the polymer used. All the batches exhibited friability within the standard limit without significant difference in values (p>0.05), indicating that tablet formulated with the experimental binders would not undergo surface abrasion. All the formulations exhibited zero order kinetics except batches DPP-10 and DPP-15 which showed Higuchi mechanism. Formulation batches DRA-05 and DRA-10 showed maximum drug release of 98% and 95% respectively after 6 h. A prolonged drug release was observed on increasing polymer ratio. Significantly higher release rates (p<0.05) were observed in the tablets formulated with PVP than those containing R. africana gum. All the batches followed non-fickian diffusion release mechanism. Conclusion:From the study, purified R. africana hydrocolloid generally appeared to perform better than PVP as sustained release agent.

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Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Cited by 3 publications

References 15 publications

Preparation and pre-clinical characterization of sustainedrelease ketoprofen implants for the management of pain and inflammation in osteoarthritis

Preparation and pre-clinical characterization of sustainedrelease ketoprofen implants for the management of pain and inflammation in osteoarthritis

Design and Evaluation of Sustained Release Matrix Tablets of Antihyperlipidemic Drug

Optimized Delivery of Diclofenac Sodium Formulated in a Sustained Release Raphia Africana Hydrocolloid Matrix

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