Preparation and characterization of titanium oxide‐densified cellulose beads for expanded bed adsorption

Abstract

Expanded bed adsorption (EBA) has been widely used in industrial downstream bioprocessing. Solid matrix is the principal pillar supporting the successful application of the EBA. A new type of TiO 2 -densified cellulose beads as matrix for EBA is exploited through the method of water-in-oil suspension thermal regeneration. The typical physical properties of beads are wet density 1.21 g/cm 3 , specific surface area 38.7 m 2 /mL, porosity 83.7%, and water content 69.5%. The results indicate that the custom-assembled matrix can be derivated to function as an anion exchanger for EBA, by possessing a significant mechanical strength, stable hydrodynamics, and comparable protein breakthrough capacities with the commercial Streamline diethylaminoethyl (DEAE) adsorbent.

Cross-linked κ-carrageenan polymer/zinc nanoporous composite matrix for expanded bed application: Fabrication and hydrodynamic characterization

“…As can be seen from Table 1, the prepared matrices have high water content due to the high hydrophilicity of -carrageenan and the effect of increasing the amount of zinc powder on reduction of matrix water content from 72.67% to 36.41% is clearly seen. In comparison to some other literatures [11,16,17,27,38] this novel matrix has higher wet density and water content. Table 1 shows that the porosity of the beads is in an excellent range which is higher than data in earlier works by Yuan [27], Yao [39] and Griffith [40].…”

“…In order to provide the special requirements of adsorbents, a small number of polysaccharides have been used to fabricate supporting matrices for chromatographic adsorption. Agarose and cellulose are the most prevalently used polysaccharides for the fabrication of customdesigned matrices such as agarose-zirconia-silica beads [13], agarose-glass beads [14], agarose-nickel [15] cellulose-titanium oxide [16], cellulose-stainless steel [17] and cellulose-nickel [18].…”

A novel method for the preparation of spherical cellulose‐tungsten carbide composite matrix with NMMO as nonderivatizing solvent

“…The physical properties were determined as reported in our previous work 31, 33, 35. Wet density (ρ p ; g/mL of wet particles) of sucked beads were determined by water replacement in a 5 mL gravity bottle.…”

“…In addition, some researcher developed new materials for EBA application, such as agarose‐alloy, fluoride modified zirconia supports, β‐cyclodextrin polymer/tungsten carbide composite matrix, etc 29, 30. In previous work, some researchers focused on the cellulose composite beads densified by some inorganic densifiers, including cellulose‐titanium oxide,31, 32 cellulose‐stainless steel,33 cellulose nickel powder,34 and cellulose‐tungsten carbide 35. The cellulose composite beads were prepared with the thermal sol‐gel transition process of cellulose xanthate viscose and showed a good performance for EBA applications.…”

Cellulose/TiO2 Hybrid Spherical Microbeads Prepared by a Viscose Phase Separation Method: Control of the Distribution of TiO2 Particles in a Sphering System

“…8 Lei et al were successful in preparation of TiO 2 -densified perfectly spherical microbeads cellulose as an anion exchanger by means of W/O phase separation using cellulose xanthate and dichlorobenzene. 9 The control of TiO 2 particles on the cellulose surface is considered to be important for the adsorption behavior of various solutes. On the other hand, cellulose microbeads prepared by the phase separation phenomenon between cellulose xanthate and polyacrylic acid aqueous soluiotn, namely the ''viscose phase separation method'', were monodisperse and spherical.…”