Preparation and clinical evaluation of a novel lozenge containing polaprezinc, a zinc-L-carnosine, for prevention of oral mucositis in patients with hematological cancer who received high-dose chemotherapy

Hayashi, Hiroko; Kobayashi, Ryo; Suzuki, Akio; Yamada, Yuto; Ishida, M.; Shakui, Toshinobu; Kitagawa, Junichi; Hayashi, Hideki; Sugiyama, Tadashi; Takeuchi, Hirofumi; Tsurumi, Hisashi; Itoh, Yoshinori

doi:10.1007/s12032-016-0795-z

Cited by 28 publications

(50 citation statements)

References 30 publications

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“…The polaprezinc lozenge can be easily taken; thus, it is suitable for outpatients and hospitalized patients. [34] The prevention management of mucositis is summarized in Table 1.…”

Section: Oral Mucositismentioning

confidence: 99%

Chemotherapy: oral side effects and dental interventions. A review of the literature

Poulopoulos¹,

Papadopoulos²,

Andreadis³

2017

SDS

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Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patients' quality of life. The aim of this review is to isolate and describe the oral side effects arising only from chemotherapy and focus on the dentist's contribution to their management. This paper comprises an extensive literature review of the main side effects affecting the oral health status of patients' undergoing chemotherapy procedures. In addition, it describes the dentist's contribution in the treatment of such patients before, throughout and after antineoplastic therapy. In conclusion, the oral cavity is a usual site of discomfort and pain caused by chemotherapy, making the dentist's contribution to the patient's relief imperative. Key words:Chemotherapy, oral side effects, oral mucositis, oral infections ABSTRACTArticle history:

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“…The polaprezinc lozenge can be easily taken; thus, it is suitable for outpatients and hospitalized patients. [34] The prevention management of mucositis is summarized in Table 1.…”

Section: Oral Mucositismentioning

confidence: 99%

Chemotherapy: oral side effects and dental interventions. A review of the literature

Poulopoulos¹,

Papadopoulos²,

Andreadis³

2017

SDS

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“…8 Various treatments for managing oral mucositis (eg, amifostine, benzydamine, and palifermin) have been proposed and tested. [9][10][11][12][13] However, most of the current interventions are only palliative and predominantly focused on improving oral hygiene and providing symptom control. 9,[12][13][14] Thus, the development of more effective treatment options for oral mucositis is highly warranted.…”

Section: Introductionmentioning

confidence: 99%

Peroxisome proliferator activated receptor‐gamma stimulation for prevention of 5‐fluorouracil‐induced oral mucositis in mice

et al. 2017

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“…In the search for recently published articles about zinc, a RCT reported that zinc sulfate reduced the incidence and severity of OM in leukemia patients undergoing CT [81]. Additionally, zinc was reported to be effective in 2 comparative studies; one conducted in HSCT and the second conducted in RT for H&N cancer [12,82].…”

Section: Discussionmentioning

confidence: 99%

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Yarom

Hovan²,

Bossi

et al. 2019

Support Care Cancer

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Purpose To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible. Results A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was reestablished. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemoradiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions. Conclusions Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.

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Preparation and clinical evaluation of a novel lozenge containing polaprezinc, a zinc-L-carnosine, for prevention of oral mucositis in patients with hematological cancer who received high-dose chemotherapy

Cited by 28 publications

References 30 publications

Chemotherapy: oral side effects and dental interventions. A review of the literature

Chemotherapy: oral side effects and dental interventions. A review of the literature

Peroxisome proliferator activated receptor‐gamma stimulation for prevention of 5‐fluorouracil‐induced oral mucositis in mice

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

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