Preparation and cytotoxicity of N-modified chitosan nanoparticles applied in curcumin delivery

Facchi, Suelen Pietrobon; Scariot, Débora B.; Bueno, Pedro V.A.; Souza, Paulo R.; Figueiredo, Luana Caroline de; Follmann, Heveline D.M.; Nunes, Cátia S.; Monteiro, Johny P.; Bonafé, Elton Guntendorfer; Nakamura, Celso V.; Muniz, Edvani C.; Martins, Alessandro F.

doi:10.1016/j.ijbiomac.2016.02.063

Cited by 72 publications

(19 citation statements)

References 35 publications

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“…( 3 ). The broad peak can be attributed to water evaporation from sodium alginate [30], whereas the sharp peak corresponds to the melting of curcumin crystals [27, 28], which suggests that the curcumin is in a crystalline form in the physical mixture. In optimized formulation (ZC) of curcumin-sodium alginate nanoparticles, there is anevidence of a sharp endothermic peak around 178.89°C, which suggests that the curcumin is in crystalline form rather than amorphous form.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Govindaraju¹,

Karki

Chandrashekarappa³

et al. 2019

PNT

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Background: The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in the south and southeast tropical Asia. Turmeric an Indian yellow gold and universal spice is described in Ayurveda, an ancient treatise on longevity and quality life for the treatment of various inflammatory disorders. The oral bioavailability of curcumin is low due to poor aqueous solubility, alkaline instability and speedy elimination. Objective: The present study is designed to prepare alginate polysorbate 80 nanoparticles to enhance aqueous solubility/dispersibility, hence bioavailability. Method: Curcumin-loaded alginate - polysorbate 80 nanoparticles were prepared by ionotropic gelation technique. Results: The optimized nano particles exhibited higher encapsulation efficiency (95%), particle size of 383 nm and Zeta potential of +200 mV. Formulations exhibited very low dissolution in Simulated Gastric Fluid (SGF) and Simulated Intestinal Fluid (SIF), but the major portion released in SCF which is attributed to the digestibility of alginate in Simulated Colonic Fluid (SCF) under the influence of colonic micro flora. FTIR and DSC observations revealed the successful entrapment of curcumin in alginate polysorbate-80 nanoparticles. The nanoparticles were more spherical, discrete and homogeneous. In healthy human volunteers, the oral bioavailability (AUC) of curcumin increased 5-fold after the consumption of curcumin nanosuspension compared to curcumin suspension. Maximum plasma concentration Cmax- 636 ± 122 ng/ml was observed at tmax- 2h for nanosuspension, whereas Cmax-87.7 ± 17.9ng/ml at tmax- 4h for suspension. Conclusion: Curcumin-loaded alginate - polysorbate 80 nanoparticles prepared by ionotropic gelation method, successfully entrapped curcumin. Both curcumin suspension and curcumin nanosuspension were safe and well tolerated and may thus be useful in the prevention or treatment of various inflammatory diseases of mankind.

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Section: Resultsmentioning

confidence: 99%

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Govindaraju¹,

Karki

Chandrashekarappa³

et al. 2019

PNT

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“…Facchi et al . [92] synthesized encapsulated curcumin nanoparticles, which consisted of N, N-dimethyl chitosan, N,N,N-trimethyl chitosan and sodium tripolyphosphate in water-in-benzyl alcohol emulsion medium. This system overcame the low solubility, high crystallinity and poor oral bioavailability of curcumin.…”

Section: New Insight Into the World Of Nutrac- Euticalsmentioning

confidence: 99%

“…This system overcame the low solubility, high crystallinity and poor oral bioavailability of curcumin. Additionally, the conducted in-vivo and in-vitro studies showed the enhanced anticancer properties of this system, as shown in Table 1 [92].…”

Section: New Insight Into the World Of Nutrac- Euticalsmentioning

confidence: 99%

Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved

Helal

Eassa

Amer³

et al. 2019

DDF

111

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: Traditional nutraceuticals and cosmeceuticals hold pragmatic nature with respect to their definitions, claims, purposes and marketing strategies. Their definitions are not well established worldwide. They also have different regulatory definitions and registration regulatory processes in different parts of the world. Global prevalence of nutraceuticals and cosmeceuticals is noticeably high with large market share with minimal regulation compared to traditional drugs. The global market is flooded with nutraceuticals and cosmeceuticals claiming to be of natural origin and sold with a therapeutic claim by major online retail stores such as Amazon and eBay. Apart from the traditional formulations, many manufacturers and researchers use novel formulation technologies in nutraceutical and cosmeceutical formulations for different reasons and objectives. Manufacturers tend to differentiate their products with novel formulations to increase market appeal and sales. On the other hand, researchers use novel strategies to enhance nutraceuticals and cosmeceuticals activity and safety. : The objective of this review is to assess the current patents and research adopting novel formulation strategies in nutraceuticals and cosmeceuticals. Patents and research papers investigating nutraceutical and cosmeceutical novel formulations were surveyed for the past 15 years. Various nanosystems and advanced biotechnology systems have been introduced to improve the therapeutic efficacy, safety and market appeal of nutraceuticals and cosmeceuticals, including liposomes, polymeric micelles, quantum dots, nanoparticles, and dendrimers. This review provides an overview of nutraceuticals and cosmeceuticals current technologies, highlighting their pros, cons, misconceptions, regulatory definitions and market. This review also aims in separating the science from fiction in the nutraceuticals and cosmeceuticals development, research and marketing.

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“…Nanoparticles exhibit significant superiority due to their ability for enhanced encapsulation and solubility of hydrophobic compounds (Tulin and Derman, 2018), suitable size for cellular uptake, viability for targeted delivery (Fang et al, 2010), and stable internalization capacity for clathrin-mediated endocytosis (Liu et al, 2018). Over the years, nanoparticles based on proteins and polysaccharides such as soy protein isolate (Yan et al, 2018), quinoa protein (Zheng and Gu, 2011;Qin et al, 2018), chitosan (Facchi et al, 2016), and Gum Arabic (Butstraen and Salauen, 2014) have gained widespread attention due to their intrinsic safety, biodegradability, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

Wang

Chen

et al. 2020

Front. Chem.

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Herein, a self-assembly formulation of Zein and dextran sulfate sodium (DSS) binary complex has been developed for the quercetin (Que) delivery. The prepared particles display a smooth sphere in the range of 180 ∼ 250 nm. The addition of DSS shields the Trp residues of Zein that were located on the hydrophilic exterior and in-turn reduces the surface hydrophobicity of the nanoparticles. The presence of DSS, indeed, increases the encapsulation efficiency of Que from the initial 45.9 in the Zein to 72.6% in the Zein/DSS binary complex. A significant reduction of Que diffusion in the simulated intestinal conditions has been observed with the addition of DSS on the nanoparticles, which also improves Que bioavailability. The release mechanism of Que-loaded Zein/DSS composites is in accordance with the Higuchi model (Q = 0.0913t 0.5 +0.1652, R 2 = 0.953). Overall, nanoparticles based on Zein-DSS complexes stand out as an attractive carrier system of quercetin and the outcome could be extended to several bioactive compounds.

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Preparation and cytotoxicity of N-modified chitosan nanoparticles applied in curcumin delivery

Cited by 72 publications

References 35 publications

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers

Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved

Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

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