Preparation and evaluation of a novel wound dressing sheet comprised of β-glucan–chitosan complex

1,3-Beta-Glucans: Drug Delivery and Pharmacology

“…Poly(vinyl alcohol)/ -glucan composite was able to speed up the wound healing process when tested using rat models and hence decreased the healing time by 48% as compared to cotton gauze [23]. When using a composite of -glucan and chitosan, a transparent dressing was obtained, which showed better results compared to commercially available chitosan based Beschitin® W. The synthesized chitosan composite did not dissolve during application period and was easy to remove because it did not adhere to wounds [22].…”

“…Beta glucan collagen matrix wound dressings have been used in children suffering from partial thickness burns and the dressings were able to simplify wound care by reducing analgesic requirements, improving cosmetic results and eliminating the need for repetitive dressing changes [86]. Other composites of -g l u c a n h a v e b e e n c r e a t e d w i t h p o l y ( v i n y l a l c o h o l ) [ 2 3 ] a n d chitosan [22]. Poly(vinyl alcohol)/ -glucan composite was able to speed up the wound healing process when tested using rat models and hence decreased the healing time by 48% as compared to cotton gauze [23].…”

“…When extracted 1,3--glucans are administered to animals or humans, they recruit macrophages and stimulate the immune system through a similar mechanism [8,9]. This result has been utilized for various pharmacological applications including cancer inhibition [10][11][12][13][14][15][16][17], infection resistance [18][19][20][21] and wound healing [22][23][24]. Current research is focusing on combining the structural properties of 1,3--glucans with the pharmacological ones to further enhance the efficacy of hybrid systems thus created.…”

The cost-effectiveness of a novel soluble beta-glucan gel

“…Beta-glucans are a heterogeneous group of natural polymers found in the cell walls of bacteria, yeast, fungi and algae, in grains (oats, barley, rye, wheat), and in seaweed. [9][10][11] Where differences exist between beta-glucans this is a result of variances in their source, solubility, structure, molecular weight and polymer charge. 12 Beta-glucans have attracted attention because they belong to a group of physiologically active compounds called biological response modifiers (BRMs).…”

Formulation and synthesis of materials with β-glucans

“…YBG resulted in an effective treatment for burn injuries in in vivo tests with rats by oral ingestion (Firat et al, 2013). They also improved the healing of injuries in mice when processed as wound dressing sheet together with chitosan (Kofuji et al, 2010). In this case, the sheets were applied over the injury and produced faster healing than a commercial chitosan wound dressing.…”