Preparation and evaluation of Bacopa–phospholipid complex for antiamnesic activity in rodents

Habbu, Prasanna; Madagundi, Smita; Kulkarni, R. D.; Jadav, Sagar K; Vanakudri, Rashmi; Kulkarni, Vaishali

doi:10.1016/j.dit.2013.02.004

Cited by 51 publications

(20 citation statements)

References 26 publications

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“…b. Another study also reveals that there is the preparation of berberine phospholipid complex solid dispersion, which not only increase the solubility of the compound but also increase its flow ability and dissolution rate for industrial production [60]. c. Another research state that there is the preparation of sinigrin phytosome.…”

Section: Advances In Phytosome Technologymentioning

confidence: 99%

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A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

Kumar

Singh

et al. 2017

Asian J Pharm Clin Res

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The poor oral bioavailability of polyphenolic compound can be enhanced through the incorporation of them into phospholipid based self-assembled delivery system, i.e. popularly known as phytosome. "Phyto" means plants and "some" resembles a covering around/or a structure. Phytosome is generally prepared by reacting one or two moles of polyphenolic phytoconstituents and phospholipid. It may be either in the ratio of 1:1 and 1:2. By using phytosomes, one can also achieve enhanced rate and extent of the passage of lipophilic herbal constituents across lipid membrane that explains its character as a carrier as well as acid labile herbal drugs could also be protected in gastrointestinal tract. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis. The present review describes an updated overview of preparation of phytosomes, advancement in phytosomes technology, various herbal drugs for which phytosomes have been used as a carrier, its commercial availability and applications.

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Section: Advances In Phytosome Technologymentioning

confidence: 99%

“…Collect the precipitate and stored in a vacuum desiccator overnight. The dried precipitate is then passed through #100 mesh size and stored in well closed ambered colored container [53]. d. Phytosomes can be prepared by reflux method.…”

Section: Preparation Techniques For Phytosomesmentioning

confidence: 99%

A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

Kumar

Singh

et al. 2017

Asian J Pharm Clin Res

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“…To determine the entire quantity of drug, 0.1 ml of the phytosome loaded suspension can be diluted in fuel, adjusting the volume to 10 ml. The entrapment efficiency may be calculated according to the subsequent formula: [13][14] Entrapment efficiency (%) = (Total amount of drug) -(amount of free drug) × 100 / (Total amount of drug)…”

Section: Entrapment Efficiencymentioning

confidence: 99%

“…Peak transition onset temperatures may be recorded by means of an instrument. [13][14][15] FTIR Spectrographic Analysis FTIR spectral data can be taken to determine the structure and chemical stability of phytosome loaded, phospholipids, polymer and drug sample. Samples can be crushed with KBr to get pellets at 600 kg/cm 2 pressure.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…Digital pictures of phytosome loaded may be taken by random scanning of the stub at 1000, 5000, 10000 and 30000 X magnifications. [13][14][15] In Vitro and In Vivo Evaluations In vitro and in vivo evaluations can be done according to therapeutic activity measurement parameters of the biologically active phytoconstituents present in the phytosomes loaded with the help of suitable animal models.…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

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Phytosome Loaded Novel Herbal Drug Delivery System: A Review

Singh¹,

Gangadharappa²,

Mruthunjaya³

2016

Int. Res. J. Pharm.

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Novel drug delivery system (NDDS) is an innovative approach to drug delivery that addresses the limitations of the traditional drug delivery systems. If the novel drug delivery system is applied in herbal drugs, it should facilitate in increasing the efficaciousness and reducing the side effects of various herbs. This is often the essential plan behind incorporating novel technique of drug delivery in herb compounds. So it's necessary to integrate novel drug delivery system and Indian Ayurvedic medicines to conflict additional serious diseases. For a long time herb medicines weren't considered for development as new formulations because of lack of scientific justification and process difficulties such as standardization, extraction and identification, purification of individual drug elements or phyto-constituents in advanced polyherbal systems. The on the market approaches for novel herb analysis will solve the scientific wants (such as determination of pharmacokinetics, mechanism and site of action, correct dose needed etc.) of herbal medicines to be incorporated in novel drug delivery system. Phytosomes are proprietary method developed by Indena, to include phospholipids into standardized extracts and then greatly improve their absorption and utilization. Phytosomes loaded are advanced herbal products made by binding individual part of herb or plant extract to phosphatidylcholine leading to a product that's higher absorbed and produces higher results than the traditional herbal extracts.

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