Preparation and evaluation of bipyridyl-tagged reagents and scavengers

Convers, Emmanuelle; Tye, Heather; Whittaker, Mark

doi:10.1016/j.tet.2004.05.106

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…Inspired by this work, Tye and co-workers have shown that the bipyridyl-tagged amine 7 was a potential isocyanate scavenger, the urea byproduct being effectively trapped by the Cu-coated resin used by Ley, Pritchard et al [28].…”

Section: Solid/liquid Separationmentioning

confidence: 95%

Pyridyl Tags as Phase Labels in Organic Synthesis: Fluorous and Non‐Fluorous Approaches

Bakkari

Vincent

2006

QSAR Comb. Sci.

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Pyridyl tags represent very attractive phase labels for reactants and reagents. Pyridyl tags are the prototypical example of "masked phase tags" which require an activation step to modify the natural phase affinity of the tagged compound. The activation is carried out by either protonation or coordination to a metal ion, whereas deactivation is achieved by basification or addition of competitive ligands. By such simple operations the tagged compounds can be reversibly switched between a liquid-organic phase and other liquid phases (aqueous or fluorous) or between a liquid-organic phase and a solid phase. The purification of reaction products can thus be achieved by straightforward liquid/liquid or solid/liquid separation procedures. Additionally, the pyridyl tags may function both as a phase label and directing tags by accelerating reactions and/or increasing their selectivity.

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Section: Solid/liquid Separationmentioning

confidence: 95%