Preparation and evaluation of Bletilla striata polysaccharide/graphene oxide composite hemostatic sponge

Chen, Junke; Lv, Ling; Liu, Ying; Ren, Xiaodong; Luo, Hao; Gao, Yuanping; Yan, Heng-Xiu; Li, Yanfang; Qu, Yan; Yang, Liu; Li, Xiujun; Zeng, Rui

doi:10.1016/j.ijbiomac.2019.02.137

Cited by 63 publications

(29 citation statements)

References 45 publications

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“…Sevage reagent (chloroform/n-butanol, 4 : 1) to the solution and stirring overnight, until the absorption of the solution at 260 nm and 280 nm was zero, then the aqueous phase was collected by centrifugation at 3500 rpm for 10 min. After decolorization, dialysis, evaporation, precipitation with ethanol, filtration, and lyophilization, the crude B. striata polysaccharides are obtained [2,3,5]. The crude extracts are redissolved and applied to different chromatographic columns described above, eluted with appropriate running buffers, collected, dialyzed, concen-trated, and lyophilized, to produce the pure B. striata polysaccharide (BSP) [2].…”

Section: Extraction and Purification Methodsmentioning

confidence: 99%

“…Reports about the Mw of various B. striata polysaccharides ranged from 10 4 to 10 5 Da. (Table 2) indicated that BSPs were a sort of glucomannan [2,5]. An early publication in 1993 first reported that BSPs contained glucose and mannose in a molar ratio of 1 : 3, with the backbone consisting of 1,4-linked aldohexopyranosyl residues [37].…”

Section: Physiochemical and Structural Featuresmentioning

confidence: 99%

“…B. striata has been widely used in traditional Chinese herbal medicine (TCM) for thousands of years and is one of the "seven white" in ancient China, mainly distributed in the Qinling Mountains and Yangtze River region [3,4]. TCM holds that B. striata is bitter, astringent, neutral, and warm and has bioactivities in alimentary canal mucosal damage, ulcers, bleeding, bruises, and burns [4,5]. Also, the functions of hemostasis, detumescence, and improving one's health of B. striata were recorded by Chinese pharmacopeia (2010) [2,6].…”

Section: Introductionmentioning

confidence: 99%

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A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

Yin

Nie

et al. 2020

BioMed Research International

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Recently, polysaccharides from Bletilla striata, a member of the orchidaceous family, aroused the wide interest of people, especially their isolation, chemical properties, and bioactivities. It is reported that these polysaccharides are the most important biologically active components of B. striata, exhibiting various biological activities, such as immunomodulatory, antioxidant, antifibrotic, and hemostatic effects. This review appraised the available literatures which described different aspects of B. striata polysaccharides, including the extraction, separation, purification, structural characterization, and biological activities. We expect to lay the foundation for further investigation of the application of B. striata polysaccharides in the field of functional foods and biomedicine.

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Section: Extraction and Purification Methodsmentioning

confidence: 99%

Section: Physiochemical and Structural Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

Yin

Nie

et al. 2020

BioMed Research International

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“…The developed aerogels exhibited the capacity for surface coagulation of whole blood, which was greatly improved by the incorporation and release of polyphenolic extracts with high content of proanthocyanidins, of potential use for wounds due to their wound healing and anti-inflammatory properties. Another bioactive natural compound, Bletilla striata polysaccharide, was combined with GO by hydrogen bonding to prepare a new composite aerogel sponge with hemostatic effect (Figure 5E) [128]. More recently, n-alkylated chitosan/graphene oxide porous sponges were developed for rapid and effective hemostasis in emergency situations [131].…”

Section: Bioaerogels Application Versus Wound Stagesmentioning

confidence: 99%

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds

et al. 2021

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Wounds affect one’s quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards healing. However, excessive production can be detrimental, representing a challenge for wound management. The design and development of new healing devices and therapeutics with improved performance is a constant demand from the healthcare services. Aerogels can combine high porosity and low density with the adequate fluid interaction and drug loading capacity, to establish hemostasis and promote the healing and regeneration of exudative and chronic wounds. Bio-based aerogels, i.e., those produced from natural polymers, are particularly attractive since they encompass their intrinsic chemical properties and the physical features of their nanostructure. In this work, the emerging research on aerogels for wound treatment is reviewed for the first time. The current scenario and the opportunities provided by aerogels in the form of films, membranes and particles are identified to face current unmet demands in fluid managing and wound healing and regeneration.

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“…Because of its obvious and non-toxic hemostatic effect, BSP has been developed as a new type of hemostatic agent that can be used as a drug delivery vehicle and wound dressing (Zhang et al, 2017a). BSP can be combined with other materials to develop new biomedical materials, such as hemostatic materials for surgical treatments (Wang et al, 2017; Chen et al, 2019).…”

Section: Pharmacologic Activitiesmentioning

confidence: 99%

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

Pan

Chen

2019

Front. Pharmacol.

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Bletilla striata is a plant from the Orchidaceae family that has been employed as a traditional Chinese medicine (TCM) for thousands of years in China. Here, we briefly review the published studies of the last 30 years that were related to chemical constituents, pharmacologic activities, and clinical applications of B. striata. Approximately 158 compounds have been extracted from B. striata tubers with clarified molecular structures that were classified as glucosides, bibenzyls, phenanthrenes, quinones, biphenanthrenes, dihydrophenanthrenes, anthocyanins, steroids, triterpenoids, and phenolic acids. These chemicals support the pharmacological properties of hemostasis and wound healing, and also exhibit anti-oxidation, anti-cancer, anti-viral, and anti-bacterial activities. Additionally, various clinical trials conducted on B. striata have demonstrated its marked activities as an embolizing and mucosa-protective agent, and its application for use in novel biomaterials, quality control, and toxicology. It also has been widely used as a constituent of many preparations in TCM formulations, but because there are insufficient studies on its clinical properties, its efficacy and safety cannot be established from a scientific point of view. We hope that this review will provide reference for further research and development of this unique plant.

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Preparation and evaluation of Bletilla striata polysaccharide/graphene oxide composite hemostatic sponge

Cited by 63 publications

References 45 publications

A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds

Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata

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