Preparation and evaluation of buccoadhesive films of atenolol

Satishbabu, BK; Srinivasan, B.P.

doi:10.4103/0250-474x.41451

Cited by 56 publications

(40 citation statements)

References 11 publications

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“…In order to ensure unidirectional drug release during the in vivo studies, a backing membrane of ethyl cellulose was adhered to the film. Backing membrane was casted by pouring 5% w/v solution of ethyl cellulose (plasticized using 2% v/v of dibutyl phthalate) onto a petri dish (Satishbabu & Srinivasan, 2008). This layer was allowed to dry similar to as explained for films.…”

Section: Formulation Of Oral Buccoadhesive Filmsmentioning

confidence: 99%

Buccal films of prednisolone with enhanced bioavailability

Kumria¹,

Nair

Goomber

et al. 2014

Drug Delivery

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The conventional formulation of prednisolone is considered to be low in efficacy, primarily on account of their failure in providing and maintaining effective therapeutic drug levels. This study aims to focus on development of a mucoadhesive buccal delivery system with a twofold objective of offering a rapid as well as a prolonged delivery of prednisolone coupled with enhanced therapeutic efficacy. Buccoadhesive films of prednisolone were prepared by solvent-casting method using hydroxyl propyl methyl cellulose (K100), Carbopol 940 and/or Eudragit NE 40 D. Placebo films possessing the most desirable physicomechanical properties were selected for drug loading. The effect of polymer and its content on film properties, i.e. mucoadhesive strength, swelling and hydration, in vitro drug release was studied. Based on these studies, film F7D was selected for ex vivo permeation across porcine cheek mucosa. The steady state flux of prednisolone across the buccal mucosa was found to be 105.33 ± 32.07 µg/cm(2)/h. A comparative pharmacokinetic study of prepared film (F7D) and oral suspension of prednisolone was conducted. In vivo data of buccal film show greater bioavailability (AUC0-α: 24.26 ± 4.06 µg.h/ml versus 10.65 ± 2.15 µg.h/ml) and higher Cmax (2.70 ± 0.38 µg/ml versus 2.29 ± 0.32 µg/ml) value when compared to oral suspension. The data observed from this study highlight the feasibility of the buccal route as a viable option for delivery of prednisolone.

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Section: Formulation Of Oral Buccoadhesive Filmsmentioning

confidence: 99%

Buccal films of prednisolone with enhanced bioavailability

Kumria¹,

Nair

Goomber

et al. 2014

Drug Delivery

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“…At the end of the study, all buccal films were removed and analyzed for the remaining drug content. [13][14][15] …”

Section: Ex Vivo Diffusion Studymentioning

confidence: 99%

Untitled

Patel¹

2017

AJP

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Aim:The main objective of the study was to assess the potential application of Chitosan/Karaya gum interpolymer complex to develop the novel rate controlled buccal mucoadhesive drug delivery system. Developed drug delivery system is capable to administer opioid analgesic drug tramadol HCl directly into systemic circulation via buccal mucosa. The developed drug delivery system would be more effective in terms of improving bioavailability, quick onset of action and reduction in dose related side effects of drugs which are suffering from hepatic first pass metabolism. Materials and Methods: Chitosan and karaya gum were selected for the preparation of interpolymer complex. Resulted interpolymer complex was characterized by Fourier-transform infrared and scanning electron microscopy. Further, the swelling behaviour of interpolymer complex was studied compare to karaya gum alone. Mucoadhesive bilayered buccal films were prepared from Interpolymer complexes by solvent casting method. An impermeable ethyl cellulose backing layer was placed to ensure unidirectional drug release from filmes. The resulted mucoadhesive buccal films were evaluated for swelling index, folding endurance, bioadhesive strength, ex vivo diffusion of the drug, in vitro dissolution and in vivo absorption of the drug. An opioid analgesic Tramadol HCl was used to study the nature of drug release from buccal films. A software aided optimization was carried out to understand the effect of formulation factors like amount of inter polymer complex and plasticizer at three different levels on three major properties of films like swelling index, tensile strength and in vitro dissolution. Result and Discussion: It has been observed that all resultant buccal films prepared by using inter polymer complex between Karaya gum and chitosan have shown good structural integrity, good mucoadhesive strength, satisfactory drug release and are capable to improve the in vivo absorption as well as plasma residence time.

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“…The impermeable backing membrane is an important part to ensure the unidirectional drug release [9]. Materials with hydrophobicity, low water permeability and drug impermeability properties such as melted wax [10], ethyl cellulose [1,4,11], and Eudragit RL100 [12] have been used as a backing membrane. A wide range of polymers such as hydroxypropyl methylcellulose, carbopol, poly (vinyl alcohol) (PVA), and poly (vinyl pyrrolidone) (PVP) [13][14][15][16][17] have been employed as a matrix and mucoadhesive layer in buccal patches.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

Jaipakdee

Limpongsa

2018

Int J App Pharm

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Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix. Conclusion:Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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Preparation and evaluation of buccoadhesive films of atenolol

Cited by 56 publications

References 11 publications

Buccal films of prednisolone with enhanced bioavailability

Buccal films of prednisolone with enhanced bioavailability

Untitled

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

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