Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools

Lafuente, Yanina de; Ochoa‐Andrade, Ana; Parente, María Emma; Palena, María Celeste; Jiménez-Kairuz, Álvaro F.

doi:10.1111/ics.12638

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…de Lafuente et al evaluated the impact of the incorporation of caffeine as a model active ingredient on the quality attributes of a bioadhesive emulgel formulation. 92 There were no significant changes in the critical quality attributes and promising stability was observed for at least one year. Moreover, the product exhibited excellent skin adhesion properties in both in vitro / ex vivo bioadhesion experiments using human skin and better caffeine delivery performance than a commercial compounding cream.…”

Section: Current Applicationsmentioning

confidence: 90%

“…The exceptional stability and tunable rheology of emulsion gels make them a promising candidate for application in food, 48,87,88 pharmaceuticals, 89,90 and cosmetics. 91,92 Furthermore, they can serve as soft templates for designing advanced materials with unique structural and functional properties. 4,26,75 In this section, the most significant and prospective applications of emulsion gels will be discussed in detail (Fig.…”

Section: Current Applicationsmentioning

confidence: 99%

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Recent progress in emulsion gels: from fundamentals to applications

et al. 2023

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Section: Current Applicationsmentioning

confidence: 90%

Section: Current Applicationsmentioning

confidence: 99%

Recent progress in emulsion gels: from fundamentals to applications

et al. 2023

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“…Since curcumin emulgels do not contain surfactant, the presence of carbopol gains importance in terms of increasing the viscosity and modifying the rheological properties. C940 provides a shear-thinning or thixotropic property, which affects the product removal or skin application and resistance to incompatibility such as creaming, flocculation or coalescence [27]. Kim et al, (2003) reported a Herschel-Bulkley type of shearthinning flow property by the use of C934 [24,28].…”

Section: Figure 1 Appearance Of Emulgels After Preparationmentioning

confidence: 99%

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

ERGİN¹,

Inal²,

BARAKAT³

2023

jrp

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Curcumin has been used in many diseases due to its high therapeutical potential in recent years. Although curcumin is a frequently used natural polyphenolic compound products, its low solubility and poor permeability limits the dermal efficacy of curcumin. Emulgels are a new generation of semi-solid formulations that combine the advantages of both emulsions and gels. The biggest limitation of emulsions is surfactant related irritation problems caused by the use of high amount of surfactants. In this study, it was aimed to increase the skin permeability of curcumin by developing surfactant-free emulgel formulations. In the study, emulgels were developed by Carbopol 940 gels as the aqueous phase, olive oil and curcumin methanol solution as the oil phase. No surfactant was used additionally to show the stabilizing effect of Carbopol in emulgels. The emulgel formulations were subjected to physicochemical characterization by means of organoleptic properties, pH, rheological and mechanical properties. Mechanical properties were carried out by texture profile analyzes to determine the structure related properties such as hardness, compressibility, adhesiveness, cohesiveness and elasticity. The spreadability of the formulations was also determined with Texture Analyzer. Obtained emulgels showed good rheological, mechanical and spreadability properties. The transdermal permeation of the chosen emulgel was studied ex vivo against hydrogel prepared with the same amount of Carbopol. The emulgel formulation significantly increased transdermal permeation compared to the hydrogel. This emulgel formulation successfully passed from stress tests. As a conclusion, the novel surfactant-free emulgel formulation was successfully developed to increase curcumin permeation through the rat skin.

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“…Sainy J, et al [29], has developed an Aloe verabased emulgel formulation of Desoximetasone (DM) for effective treatment of plaque psoriasis and found to increase in in vitro permeation of drug from Aloe vera emulgel and could be employed for the topical treatment of skin ailments. de Lafuente Y, et al [30], evaluated the influence of the incorporation of caffeine in bioadhesive emulgel formulationand results suggested that the optimized emulgel could be an interesting topical biodhesive delivery system for cosmetic applications. Morsy MA, et al [31], formulated and evaluated the efficacy of topical application of ATR-based nanoemulgel on wound healing.…”

Section: Topical Applicationsmentioning

confidence: 99%

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

Amgaonkar¹,

Kochar²,

Chandewar³

et al. 2021

JPRI

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Emulgel is an emerging delivery system with added advantages over other topical delivery systems which is proven to be boon for cosmetics and dermatology. Emulgels are emulsion which is converted to Gel, which will make it a non greasy and enhances patient compliance. The amalgamation of the two systems would be advantages in term of high drug loading capacity and low skin irritation, site specific targeting avoiding first-pass metabolism and increase in bioavailability. Work carried out by researchers proved that, Emulgel/ Nanoemulgel loaded with drugs has been found effective in many topical disorders and it is emerging as potential drug delivery system in area of dermatology. In the present review current research works that carried out on Emulgel and nano emulgels are discussed and also highlighted the recent applications of Emulgel in transdermal as well as dental, ocular, vaginal, and other delivery system.

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Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools

Cited by 11 publications

References 21 publications

Recent progress in emulsion gels: from fundamentals to applications

Recent progress in emulsion gels: from fundamentals to applications

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

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