Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Abstract

Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis. 
 Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activity