Preparation and Evaluation of Chitosan Sodium Alginate Carbamazepine Microspheres

Abstract

Objective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres for the purpose of controlled release for the treatment of epilepsy to avoid the possible side effects. Methods:The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into the natural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies. Results:The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within the acceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation (CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy. Conclusion:The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.