No abstract

Background:A novel drug delivery system for treating acute epileptic condition.Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded insitu gel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range. Invitro drug release from the mucoadhesive insitu gel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min. Exvivo permeation studies of optimized formulation G5 and control formulation was estimated. Exvivo permeation studies of G5 insitu formulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).Conclusion:The intranasal insitu gelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.

Objective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres for the purpose of controlled release for the treatment of epilepsy to avoid the possible side effects. Methods:The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres with the dispersion of CBZ into the natural polymers chitosan and sodium alginate forming microspheres conducting along with their evaluation studies. Results:The formulated microspheres were subjected to various evaluation parameters, and all the physical parameters examined are within the acceptable limits. Further, the optimized microsphere formulation (CM5) was characterized. Hence, the developed optimized microsphere formulation (CM5) seems to be a viable substitute to conventional drug delivery system for the effective management of epilepsy. Conclusion:The prepared formulation also provides a desired CBZ loaded sodium alginate microspheres with the controlled release drug delivery.