Preparation and evaluation of magnetic microspheres of mesalamine (5-aminosalicylic acid) for colon drug delivery

Kakar, Satinder; Batra, Deepa; Singh, Ramandeep

doi:10.1016/s2221-6189(13)60132-8

Cited by 13 publications

(12 citation statements)

References 15 publications

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“…For the protection and delivery of drugs to the tumor cells, the NLCs were used. Hence, tumor targeted codelivery of PTX and ICG mediated by NLC could be a effective strategy for cancer therapy [62][63][64].…”

Section: Paclitaxel (Ptx) and Indocyanine Green (Icg) For Laser-triggmentioning

confidence: 99%

Nanostructured Lipid Carriers: The Frontiers in Drug Delivery

Chandana

Gupta

Kanna

2019

Asian J Pharm Clin Res

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By the modification of solid-lipid nanoparticles (SLNs), the nano-structured lipid carriers (NLCs) were obtained by the modification of nanostructured that hold the qualities of the SLN, increases the stability of the drug, and prevents drug leakage. The limitations of the drugs that are delivered in the body using different routes are poor solvency, first pass metabolism, and poor bioavailability hence to overcome these limitations NLCs were prepared. Oral, topical, transdermal, ocular, and parenteral are the different routes through which nanobased systems are delivered. Spatially incompatible liquid lipids and solid lipids are blended and NLCs were prepared. It stays solid at room temperature. The advantages of for drug therapy over conventional carriers NLCs are increased solubility, improved bioavailability. This review describes about the NLC, its advantages and disadvantages, types, NLC techniques, mode of action, and applications of NLC. Imperfect, amorphous, and multiple types are the main three types of NLCs. Lipids, liquid lipids, solid lipids, Emulsifiers, ultraviolet (UV) blockers, and aqueous medium were the excipients used. Microemulsion technique, microemulsion based SLN/NLC preparations, solvent diffusion method, high-pressure homogenization (HPH), hot and cold homogenization techniques, and melt emulsification method are the techniques used for the preparation of NLC. The applications of NLCs are for ocular, brain targeting, topical, cancer therapy, cosmetics, and analgesia.

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Section: Paclitaxel (Ptx) and Indocyanine Green (Icg) For Laser-triggmentioning

confidence: 99%

Nanostructured Lipid Carriers: The Frontiers in Drug Delivery

Chandana

Gupta

Kanna

2019

Asian J Pharm Clin Res

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“…Microspheres were prepared by phase separation emulsion polymerization method. Several batches of magnetic microspheres were prepared in different drug: polymer ratio using three polymers separately namely chitosan, eudragit S 100, ethylcellulose (Kakar et al, 2013). The scheme for preparation has been summarized in Table 1.…”

Section: Drug Polymer Interaction Studiesmentioning

confidence: 99%

Preparation of magnetic microspheres of mesalamine by phase separation emulsion polymerisation technique

Kakar¹,

Singh²

2014

Afr. J. Pharm. Pharmacol.

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The study involved magnetic microspheres of mesalamine prepared by phase separation emulsion polymerization (PSEP) method technique. Magnetic microspheres were prepared by PSEP method to target them to the colon. Three polymers namely Eudragit S 100, ethylcellulose and chitosan were used for the preparation of magnetic microspheres. Magnetite content and entrapment of mesalamine was evaluated. Eudragit S 100, ethylcellulose and chitosan were used as polymers. Fourier transform infrared spectroscopy (FTIR) spectrum of drug and polymer was taken to visualize the compatibility of drug and polymer. Scanning electron microscope (SEM) images show the uniformity and particle size of the microspheres formed. The in vitro release study was carried out in phosphate buffer pH 6.8. The various results obtained were fit into the mathematical models and the Higuchi model was found to be most suitable for the formulations. Chitosan magnetic microspheres prepared by phase separation emulsion polymerization were found to be best in all the evaluation parameters (practical yield, magnetite content, magnetic responsivity of microspheres, particle size, in vitro release studies). They contain maximum magnetite content which is the utmost feature for the magnetic microspheres. Microspheres can be targeted by the external magnetic field applied due to magnetite entrapped. Thus toxicity and reticuloendothelial clearance can be minimized.

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“…Initial volume was noted. Bulk density and tapped density were noted using tapping method using 10 ml measuring cylinder (Kakar et al, 2013). Angle of repose (θ), Hausner's ratio (H) and Carr's index (%C) were calculated to study the flow properties of microspheres by using the following formulas:…”

Section: Micromeritic Propertiesmentioning

confidence: 99%

6-Thioguanine loaded magnetic microspheres as a new drug delivery system to cancer patients

Kakar¹,

Singh²

2014

Afr. J. Pharm. Pharmacol.

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Magnetic microspheres of 6-thioguanine were prepared by continuous solvent evaporation technique. An attempt was made to target the magnetic microspheres to the cancerous site. Poly lactic acidpolyethylene glycol copolyester (PLA-co-PEG) was used as a polymer. Microspheres were characterized in terms of percentage practical yield, micromeritic properties, particle size, swelling kinetics, magnetic responsiveness, magnetite content and in vitro drug release study. Phosphate buffer pH 7.4 was used for in vitro release study. Microspheres were found to give sustained release pattern. Reticuloendothelial clearance can be minimized and target site specificity can be increased.

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Preparation and evaluation of magnetic microspheres of mesalamine (5-aminosalicylic acid) for colon drug delivery

Cited by 13 publications

References 15 publications

Nanostructured Lipid Carriers: The Frontiers in Drug Delivery

Nanostructured Lipid Carriers: The Frontiers in Drug Delivery

Preparation of magnetic microspheres of mesalamine by phase separation emulsion polymerisation technique

6-Thioguanine loaded magnetic microspheres as a new drug delivery system to cancer patients

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