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The study involved magnetic microspheres of mesalamine prepared by phase separation emulsion polymerization (PSEP) method technique. Magnetic microspheres were prepared by PSEP method to target them to the colon. Three polymers namely Eudragit S 100, ethylcellulose and chitosan were used for the preparation of magnetic microspheres. Magnetite content and entrapment of mesalamine was evaluated. Eudragit S 100, ethylcellulose and chitosan were used as polymers. Fourier transform infrared spectroscopy (FTIR) spectrum of drug and polymer was taken to visualize the compatibility of drug and polymer. Scanning electron microscope (SEM) images show the uniformity and particle size of the microspheres formed. The in vitro release study was carried out in phosphate buffer pH 6.8. The various results obtained were fit into the mathematical models and the Higuchi model was found to be most suitable for the formulations. Chitosan magnetic microspheres prepared by phase separation emulsion polymerization were found to be best in all the evaluation parameters (practical yield, magnetite content, magnetic responsivity of microspheres, particle size, in vitro release studies). They contain maximum magnetite content which is the utmost feature for the magnetic microspheres. Microspheres can be targeted by the external magnetic field applied due to magnetite entrapped. Thus toxicity and reticuloendothelial clearance can be minimized.

Magnetic microspheres of 6-thioguanine were prepared by continuous solvent evaporation technique. An attempt was made to target the magnetic microspheres to the cancerous site. Poly lactic acidpolyethylene glycol copolyester (PLA-co-PEG) was used as a polymer. Microspheres were characterized in terms of percentage practical yield, micromeritic properties, particle size, swelling kinetics, magnetic responsiveness, magnetite content and in vitro drug release study. Phosphate buffer pH 7.4 was used for in vitro release study. Microspheres were found to give sustained release pattern. Reticuloendothelial clearance can be minimized and target site specificity can be increased.