Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of ephedrine enantiomers

Balamurugan, Krishnamoorthy; Gokulakrishnan, K.; Prakasam, Tangirala

doi:10.1016/j.arabjc.2011.06.024

Cited by 28 publications

(8 citation statements)

References 37 publications

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“…MIPs have been employed in numerous applications apart from sensing. These applications include targeted drug delivery, − in some ways the opposite of drug sensing, chromatographic separations of related molecules and food adulterants, − …”

Section: Applications Of Mipsmentioning

confidence: 99%

Molecularly Imprinted Polymers

2018

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Molecularly imprinted polymers are synthetic receptors for a targeted molecule. As such, they are analogues of the natural antibody–antigen systems. In this review, after a recounting of the early history of the general field, we specifically focus on the application of these polymers as sensors. In these applications, the polymers are paired with a reporting system, which may be electrical, electrochemical, optical, or gravimetric. The presence of the targeted molecule effects a change in the reporting agent, and a calibrated quantity of the target is recorded. In this review, we describe the imprinted polymer production processes, the techniques used for reporting, and the applications of the reported sensors. A brief survey of recent applications to gas-phase sensing is included, but the focus is primarily on the development of sensors for targets in solution. Included among the applications are those designed to detect toxic chemicals, toxins in foods, drugs, explosives, and pathogens. The application of computational chemistry to the development of new imprinted polymers is included as is a brief assessment of future developments.

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Section: Applications Of Mipsmentioning

confidence: 99%

Molecularly Imprinted Polymers

2018

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“…53 Heterogeneity is considered to be an undesirable property of MIPs and is considered to be a prime contributor of broad and asymmetric elution peaks in chromatographic applications. 56 Heterogeneity also limits the sensitivity of sensors and decreases the linearity in immunoassay-type analyses. 57,58 Thus, the applicability of the Toth isotherm to the heterogeneity of MIPs, at least 13 different isotherms are selected.…”

Section: Characterisation Of Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

Probing adsorbent heterogeneity using Toth isotherms

et al. 2021

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“…Ephedrines: 2016 fluorescence resonance energy transfer (FRET) assay for detection of ephedrine [ 970 ]; a novel sensor for the determination of ephedrine [ 971 ]; evaluation of a molecularly imprinted polymer liquid chromatography column for the separation of ephedrine enantiomers [ 972 ]; determination of five alkaloids including ephedrine, norephedrine, and methylephedrine by HPLTC-ESI-MS [ 833 ]; fluorescence-detected circular dichroism spectroscopy of ephedrine [ 973 ]; differential mobility spectrometry for the differentiation of ephedrine and pseudoephedrine [ 974 ]; detection of ephedrine by HPLC, CE and GC-MS [ 970 ]; LC-MS/MS method for quantification of five ephedrines in supplements [ 975 ]; 2017 a new portable quantum cascade laser spectrometer to perform the automated recognition of ephedrines based on their vibrational absorptions [ 976 ]; detection of controlled amphetamines and ephedrines based on Laser Infrared Spectra [ 977 ]; Two-dimensional correlation spectroscopy for the identification of ephedrine and pseudoephedrine present in illegally adulterated slimming herbal products [ 978 ]; hydrophilic interaction LC-MS/MS for the analysis of ephedrine in a pharmaceutical solid dosage form available on the internet [ 979 ]; 2018 HPLC method for the simultaneous analysis of ephedrine HCl, guaifenesin and synthetic additives in syrup samples [ 980 ]; GC-MS method for quantification of ephedrine [ 981 ]; chiral and stable isotope ratios of ephedrine synthesized via the Akabori-Momotani reaction [ 982 ]; molecularly imprinted polymer for the detection of ephedrine [ 983 ]; 2019 sensor for detection of ephedrine in liquid and solid samples [ 984 ]; identification and characterization of three compounds obtained from ephedrine (Ephedrone (methcathinone) hydrochloride, N-acetylephedrine and N-acetylephedrone) using GC-MS, NMR, IR, RAMAN and X-ray Crystallography [ 275 ].…”

Section: Routine and Improved Analyses Of Abused Substancesmentioning

confidence: 99%